The Actin Cytoskeleton and Bacterial Infection

Herausgegeben:Mannherz, Hans Georg

• Broschiertes Buch

Produktbeschreibung

This volume describes the mechanisms which bacteria have created to secure their survival, proliferation and dissemination by subverting the actin cytoskeleton of host cells. Bacteria have developed a veritable arsenal of toxins, effector proteins and virulence factors that allow them to modify the properties of the intracellular actin cytoskeleton for their own purposes. Bacterial factors either modify actin directly as the main component of this part of the cytoskeleton or functionally subvert regulatory or signalling proteins terminating at the actin cytoskeleton.
In short, this volume provides an overview of the various tricks bacteria have evolved to "act on actin" in order to hijack this essential host cell component for their own needs. As such, it will be of interest to scientists from many fields, as well as clinicians whose work involves infectious diseases.

Produktdetails

• Current Topics in Microbiology and Immunology 399
• Verlag: Springer / Springer International Publishing / Springer, Berlin
• Artikelnr. des Verlages: 978-3-319-84305-6
• Softcover reprint of the original 1st ed. 2017
• Seitenzahl: 252
• Erscheinungstermin: 13. Juli 2018
• Englisch
• Abmessung: 235mm x 155mm x 14mm
• Gewicht: 391g
• ISBN-13: 9783319843056
• ISBN-10: 3319843052
• Artikelnr.: 53584082

Autorenporträt

Hans Georg MannherzRuhr-Universität BochumInstitut für AnatomieAbteilung für Anatomie und molekulare Embryologiee-mail: [e-mail]

Inhaltsangabe

Actin structure and dynamics.- Influence of binary actin-depolymerizing toxins on the microtubule system.- ADP-ribosylation of actin by Photorhabdus luminescens TccC3 inhibits interaction with actin binding proteins essential for treadmilling.- Pathogenic mechanisms of actin cross-linking toxins - peeling away the layers.- New concepts on bacterial effectors targeting Rho GTPases.- Interaction of bacterial ADPribosyltransferases with actin.- Yersinia's ways to activate and inactivate actin rearrangements in host cells.- The role of formins in phagocytosis of Borrelia by macrophages.