Thomas Kindt

The Antibody Enigma

• Broschiertes Buch

Produktbeschreibung

The Antibody Enigma is a somewhat personal view of the antibody diversity question from two investigators who have spent the past 18 years trying to penetrate the enigma. It is not and was not meant to be an all-embracing comprehensively referenced review of the subject of antibody diversity. Because of the subjective viewpoint, there are un doubtedly omissions of data that others consider to be seminal, and if we have offended anyone by omitting their own contribution we sin cerelyapologize. We have lived with "The Enigma" on and off for the past two years. It has been both hard work and good fun but, above all, it has been a learning experience. There were several difficult decisions to make in putting together the final text, but perhaps the most difficult was de ciding upon a stopping point. The field of antibody diversity is presently enjoying an unparalleled expansion of information, and because of this it was very tempting to await further developments in hopes of tying upas many loose ends as possible. This was decided against for several reasons; the major factor was that the project was growing burdensome for both of us. From a more objective point of view this appears to be a reasonable time to stop our exposition.

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Produktdetails

• Verlag: Springer / Springer US / Springer, Berlin
• Artikelnr. des Verlages: 978-1-4684-4678-4
• Softcover reprint of the original 1st ed. 1984
• Seitenzahl: 292
• Erscheinungstermin: 8. März 2012
• Englisch
• Abmessung: 229mm x 152mm x 16mm
• Gewicht: 427g
• ISBN-13: 9781468446784
• ISBN-10: 1468446789
• Artikelnr.: 39495005

Inhaltsangabe

1. The Nature of the Problem.- 1.1. Introduction.- 1.2. Antibody Synthesis.- 1.3. Historical Roots.- 1.4. Clonal Selection.- 1.5. Effector Functions.- >1.6. The Extent of Diversity-The Problem in a Nutshell.- 1.7. Scope of the Book.- 1.8. Precis.- References and Bibliography.- 2. The Serologist's Approach to the Problem.- 2.1. Introduction.- 2.2. Rabbit Allotypes.- 2.3. Human Allotypes.- 2.4. Allotypes of the Mouse and the Rat.- 2.5. Individual Antigenic Specificity and Idiotypy.- 2.6. Idiotypes as Markers for Antibody-Binding Regions.- 2.7. The Inheritance of Idiotypes.- 2.8. Conclusion.- References and Bibliography.- 3. The Biochemist's Approach to the Problem.- 3.1. Biochemical Studies on Heterogeneous Antibodies.- 3.2. Biochemical Studies on Homogeneous Antibodies.- 3.3. Structural Features of Immunoglobulin Isotypes and Allotypes.- 3.4. Structural Features of V Regions.- 3.5. Are the C Regions Really Constant?.- 3.6. Structural Analysis of Selected V Regions.- 3.7. Precis.- References and Bibliography.- 4. Unique Features of the Antibody Problem.- 4.1. Introduction.- 4.2. Structural Variability of Antibodies.- 4.3. Two Genes-One Polypeptide Chain.- 4.4. Allelic Exclusion.- 4.5. The Three Loci for Immunoglobulins.- 4.6. Conclusion.- References and Bibliography.- 5. The Polar Solutions.- 5.1. Introduction.- 5.2. The Germline Theory.- 5.3. The Somatic Mutation Theory.- 5.4. Data Favoring Germline Theories.- 5.5. Data Favoring Somatic Mutation Models.- 5.6. Waiting for the Answer.- References and Bibliography.- 6. The Maverick Solutions.- 6.1. Introduction.- 6.2. Data Difficult to Rationalize with Either Germline or Somatic Theories.- 6.3. The Maverick Solutions.- 6.4. Precis.- References and Bibliography.- 7. The Molecular Biologists Attack the Problem.- 7.1.Introduction.- 7.2. Gene Counting by Liquid Hybridization.- 7.3. Recombinant DNA Methods.- 7.4. The Two-Gene Hypothesis Reinvestigated.- 7.5. Heavy Chain Genes.- 7.6. The V Gene Segment.- 7.7. Heavy Chain C-Region Genes.- 7.8. Allelic Exclusion.- 7.9. Mapping the Immunoglobulin Genes.- 7.10. Conclusions.- References and Bibliography.- 8. Antibody Diversity: A Contemporary Solution.- 8.1. Introduction.- 8.2. There Are a Modest Number of Germline Genes.- 8.3. Combinatorial Joining of V/J and V, D, and J Gene Segments.- 8.4. Junctional Diversity Is Created by Alternate Frames of Recombination between Germline V, D, and J Gene Segments.- 8.5. Somatic Mutation in All Gene Segments Leads to Further Diversity.- 8.6. The Number of C-Region Genes Is Limited and Varies Considerably among the Species.- 8.7. Further Considerations for Antibody Diversity.- 8.8. Gene Families and Specificity.- 8.9. V-Region Polymorphism.- 8.10. Evolution of V and J Gene Segments.- 8.11. Somatic Mutation Revisited.- 8.12. Why Do We Have Certain Germline Genes?.- 8.13. Horizons.- 8.14. Precis.- References and Bibliography.