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High Quality Content by WIKIPEDIA articles! The Big Bang Theory is an American sitcom created and executively produced by Chuck Lorre and Bill Prady. It premiered on CBS September 24, 2007. Set in Pasadena, California, the show is about two male Caltech prodigies in their 20s, one an experimental physicist (Leonard Hofstadter) and the other a theoretical physicist (Sheldon Cooper), who live across the hall from an attractive blonde waitress with show-biz aspirations (Penny). Leonard and Sheldon's 'geekiness' and sheer intellect are contrasted with Penny's social skills and common sense for comic effect.