The Biology and Therapeutic Application of Mesenchymal Cells, 2 Volume Set

Herausgeber: Atkinson, Kerry

• Gebundenes Buch

Produktbeschreibung

The Biology and Therapeutic Application of Mesenchymal Cells comprehensively describes the cellular and molecular biology of mesenchymal stem cells and mesenchymal stromal cells, describing their therapeutic potential in a wide variety of preclinical models of human diseases and their mechanism of action in these preclinical models. Chapters also discuss the current status of the use of mesenchymal stem and stromal cells in clinical trials in a wide range of human diseases and disorders, for many of which there are limited, or no other, therapeutic avenues. * Provides coverage on both the biology of mesenchymal stem cells and stromal cells, and their therapeutic applications * Describes the therapeutic potential of mesenchymal stem and stromal cells in a wide variety of preclinical models of human diseases and their mechanism of action in these preclinical models * Discusses the current status of mesenchymal stem and stromal cells in clinical trials in a wide range of human diseases and disorders, for many of which there are limited, or no other, therapeutic avenues * Written and edited by leaders in the field The Biology and Therapeutic Application of Mesenchymal Cells is an invaluable resource for those studying stem cells, cell biology, genetics, gene or cell therapy, or regenerative medicine.

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Produktdetails

• Verlag: Wiley
• Seitenzahl: 1048
• Erscheinungstermin: 17. Januar 2017
• Englisch
• Abmessung: 284mm x 224mm x 51mm
• Gewicht: 3152g
• ISBN-13: 9781118907511
• ISBN-10: 1118907515
• Artikelnr.: 44214907

Autorenporträt

Kerry Atkinson, MBBS MD DTM&H FRCP FRACP, is an Adjunct Professor at the University of Queensland Centre for Clinical Research in Brisbane, Australia, an Adjunct Professor in the Stem Cell Laboratories, Queensland University of Technology at the Translational Research Institute, Brisbane, Queensland, Australia and a Specialist in Internal Medicine at the Salisbury Medical Centre, Brisbane, Queensland, Australia.

Inhaltsangabe

Contributors, xxvii
Editor's Preface, xxxv
Section I: An overview of mesenchymal stem cells and mesenchymal stromal
cells
1 The mesenchymal stem cell, the mesenchymal stromal cell, and the
mesenchymal stromal cell exosome, 3
Kerry Atkinson
2 The nomenclature of mesenchymal stem cells and mesenchymal stromal cells,
8
Armand Keating
Section II: The isolation and ex vivo expansion of mesenchymal stromal
cells
3 The isolation and expansion of mesenchymal stromal cells from bone
marrow, 13
Celena F. Heazlewood
4 The biology and clinical applications of mesenchymal stromal cells
derived from human gestational tissues, 24
Celena F. Heazlewood
5 Human placenta-derived mesenchymal stem/stromal cells: fetal and maternal
origins and critical parameters for
ex vivo expansion, 32
Rebecca A. Pelekanos and Varda S. Sardesai
Section III: The cellular and molecular biology of mesenchymal stromal
cells
6 Epigenetic regulation of mesenchymal stem/stromal cell growth and
multipotentiality, 41
Sarah Elizabeth Hemming, Dimitrios Cakouros, and Stan Gronthos
7 Biological changes in human mesenchymal stromal cells during monolayer
culture, 58
Marietta Herrmann and Jennifer J. Bara
8 The effect of three-dimensional aggregates on the biology of mesenchymal
stromal cells, 75
Yijun Liu, Ang-Chen Tsai, Xuegang Yuan, and Teng Ma
9 Cell-cell signaling pathways that regulate mesenchymal stromal cell
differentiation, 91
Leah Etheridge, Rebecca A. Mason, Fatima Saleh, and Paul Genever
10 Regulation of mitochondrial transport in mesenchymal stromal cells, 104
Shravani Mukherjee, Naveen K. Bhatraju, Tanveer Ahmad, and Anurag Agrawal
11 The regulation of adipogenesis from adipose-derived stem/stromal cells,
114
Lin Chen and Lei Liu
12 Modulation of osteogenic differentiation in mesenchymal stromal cells,
131
Sean Gaynard, Jessica Hayes, and Mary Murphy
13 The role of glycogen synthase kinase-3 inhibitors on bone remodeling,
148
K. Jane Escott and Patrick J. O'Shea
14 Early molecular events during in vitro chondrogenesis, 167
Tommy A. Karlsen, Rune B. Jakobsen, and Jan E. Brinchmann
15 The role of the extracellular matrix in the differentiation of
mesenchymal stromal cells, 191
Peishun Shou, Qing Chen, and Yufang Shi
16 Effects of hypoxic culture on bone marrow multipotent mesenchymal
stromal cells: from bench to bedside, 196
Shih-Chieh Hung
17 The role of cyclic tensile strain on osteogenesis and angiogenesis in
human mesenchymal stem/stromal cells, 208
Adisri Charoenpanich, Josephine Bodle, and Elizabeth Loboa
18 The evolving concept of mesenchymal stromal cells in regenerative
medicine: from cell differentiation to
secretome, 222
F.G. Teixeira, A. Pires, S.C. Serra, N. Sousa, and A.J. Salgado
19 The secretome of mesenchymal stem/stromal cells undergoing chondrogenic
differentiation and those undergoing osteogenic or adipogenic
differentiation, 236
Beatriz Rocha, Francisco J. Blanco, and Cristina Ruiz-Romero
20 Mesenchymal stromal cell extracellular vesicles/exosomes, 250
Ronne Wee Yeh Yeo, Ruenn Chai Lai, and Sai Kiang Lim
21 Role of tunneling nanotube crosstalk with distressed cardiomyocytes in
controlling the heart repair potential of mesenchymal stromal cells, 264
Anne-Marie Rodriguez and Meriem Mahrouf-Yorgov
22 The preferential homing of mesenchymal stromal cells to sites of
inflammation, 286
Catherine Sullivan
23 The role of chemokines in mesenchymal stromal cell homing to sites of
inflammation, including infarcted
myocardium, 314
Shan Wang and Yaojiong Wu
24 Live cell imaging and single cell tracking of'mesenchymal stromal cells
in vitro, 323
James A. Cornwell, Maria Z. Gutierrez, Richard P. Harvey and Robert E.
Nordon
25 The role of mesenchymal stem/stromal cells in angiogenesis, 347
Annelies Bronckaers and Ivo Lambrichts
26 The relationship between mesenchymal stromal cells and endothelial
cells, 366
Seyed Mahdi Nassiri and Reza Rahbarghazi
27 The radioresistance of mesenchymal stromal cells and their potential
role in the management of radiation injury, 391
Tara Sugrue, Irene Calvo-Asensio, and Rhodri Ceredig
28 The implications of multipotent mesenchymal stromal cells in tumor
biology and therapy, 415
Pratika Y. Hernanda, Maikel P. Peppelenbosch, and Qiuwei Pan
29 Mesenchymal stem/stromal cell therapy: mechanism of action and host
response, 426
Aideen Ryan, Mary Murphy, and Frank Barry
30 The differences between mesenchymal stromal cells and fibroblasts, 441
Luigi Balducci, Sharon Natasha Cox, and Giulio Alessandri
31 Derivation of mesenchymal stem/stromal cells from induced pluripotent
stem cells, 456
Rebecca A. Pelekanos
32 The role of mesenchymal stem cells in hematopoiesis, 467
Jean-Pierre Levesque, Rebecca N. Jacobsen, and Ingrid G. Winkler
33 The modulatory effects of mesenchymal stromal cells onthe innate immune
system, 481
Ko-Jiunn Liu, Men-Luh Yen, Li-Tzu Wang, and B. Linju Yen
34 The modulatory effects of mesenchymal stromal cells on the adaptive
immune system, 490
B. Linju Yen, Ko-Jiunn Liu, Men-Luh Yen, and Huey-Kang Sytwu
35 The role of mesenchymal stromal cells in the repair of acute organ
injury, 496
A.A. Temnov, A.V. Vagabov, A.N. Sklifas, V.I. Novoselov, and Y.A. Belyi
36 The use of mesenchymal stromal cells in the treatment of diseases of the
cornea, 524
Damien G. Harkin, Allison J. Sutherland, Laura J. Bray, Leanne Foyn, Fiona
J. Li, and Brendan G. Cronin
37 The role of paracrine factors secreted by mesenchymal stromal cells in
acute tissue injury, 544
Ying Wang, Tania Velletri, Chunxing Zheng, and Yufang Shi
38 Treatment of lung disease by mesenchymal stromal cell extracellular
vesicles, 553
Antoine Monsel, Ying-gang Zhu, Varun Gudapati, and Jae-Woo Lee
39 Evaluating mesenchymal stem/stromal cells for treatment of asthma and
allergic rhinitis, 573
Tatyana Gavrilova, Saritha Kartan, Lauren S. Sherman, Oleta A. Sandiford,
and Pranela Rameshwar
40 Stem cell therapies for Huntington's disease, 581
A.T. Crane, J. Rossignol, and G. L. Dunbar
Section IV: The role of bioengineering in the therapeutic applications of
mesenchymal stromal cells
41 Endometrial mesenchymal stromal cell and tissue engineering for pelvic
organ prolapse repair, 601
Shanti Gurung, Jerome A. Werkmeister, and Caroline E. Gargett
42 Closed automated large-scale bioreactors for manufacturing mesenchymal
stromal cells for clinical use, 616
Kerry Atkinson, Nicholas Timmins, G. Kiel, Celena Heazlewood, Michael
Doran, and Gary Brooke
Section V: GMP manufacturing of mesenchymal stromal cells for clinical use
43 Current good manufacturing practice for the isolation and ex vivo
expansion of mesenchymal stromal cells derived from term human placenta for
use in clinical trials, 621
Kerry Atkinson, Dahlia Khalil, Celena Heazlewood, and Nina Ilic
44 A comparison of high-tier regulatory documents pertaining to biologic
drugs including mesenchymal stromal cells in Australia, Europe, and the USA
using a manual documentary analysis, 628
Nina Ilic
Section VI: The therapeutic application of mesenchymal stromal cells
45 The use of mesenchymal stromal cells in acute and chronic heart disease,
647
Ariel Wolf, Wayne Balkan, and Joshua Hare
46 The role of mesenchymal stem/stromal cells in the management of critical
limb ischemia, 661
P.K. Gupta, Chullikana Anoop, Balasubramanian Sudha, R Mathiazhagan, Raj
Swathi Sundar, and Majumdar Anish Sen
47 The role of mesenchymal stromal cells in the management of
musculoskeletal disorders, 677
Stefan Zwingenberger, Ishaq Ojodu, Maik Stiehler, and Stuart B. Goodman
48 The potential role of bone marrow mesenchymal stromal cells in the
treatment of ischemic stroke, 690
Yujun Pan and Ruohan Sun
49 The role of mesenchymal stromal cells in spinal cord injury, 714
P. Jendelova, L. Machova-Urdzikova, and E. Sykova
50 The role of mesenchymal stromal cells in the treatment of ulcerative
colitis and Crohn's disease, 730
Céline Gregoire, Chantal Lechanteur, Alexandra Briquet, Etienne Baudoux,
Olivier Giet, Olivier Delloye, Frédéric Baron, Edouard Louis, and Yves
Beguin
51 Mesenchymal stromal cells targeting kidney disease: benefits of a
combined therapeutic approach, 754
Brooke M. Huuskes and Sharon D. Ricardo
52 The biology and potential clinical applications of mesenchymal stromal
cells in diseases of the lung, 770
Yuben P. Moodley, Jesse D. Armitage, and Dino B.A. Tan
53 The role of mesenchymal stromal cells in diseases of the lung, 787
Kerry Atkinson
54 Mesenchymal stromal cells for the treatment of'autoimmune diseases, 794
Christopher N. Lewis and Jacques Galipeau
55 The role of mesenchymal stromal cells in bacterial infection, 814
Sailaja Ghanta, Konstantin Tsoyi, and Mark A. Perrella
56 The use of mesenchymal stromal cells in solid organ transplantation, 825
Céline Gregoire, Alexandra Briquet, François Jouret, Chantal Lechanteur,
Etienne Baudoux, Olivier Giet, Olivier Delloye, Frédéric Baron, Olivier
Detry, and Yves Beguin
57 The role of mesenchymal stromal cells in allogeneic hematopoietic stem
cell transplantation, 836
Kerry Atkinson
58 The role of mesenchymal stromal cells in the management of skin wounds,
841
Sung-Whan Kim
59 The role of mesenchymal stromal cells in skin wound healing, 845
Miao Teng and Hengshu Zhang
Section VII: Mesenchymal stromal cells as delivery vehicles for therapeutic
agents
60 The role of mesenchymal stromal cells in human brain tumors, 859
Brittany C. Parker Kerrigan, Tal Shahar, Shinji Yamashita, and Frederick F.
Lang
61 Mesenchymal stromal cells as gene delivery vehicles to treat
nonmalignant diseases, 873
Julie R. Beegle, Jan A. Nolta, and Fernando A. Fierro
62 Gene therapy for cancer using mesenchymal stromal cells, 892
Ryosuke Uchibori and Keiya Ozawa
Section VIII: The present and the future
63 Breaking news, 901
Kerry Atkinson
64 Reconciling the stem cell and paracrine paradigms of mesenchymal stem
cell function, 912
Siddaraju V. Boregowda and Donald G. Phinney
Glossary, 927
Index, 949