Stress, diet, global warming and low level EMF pollution leads to endosymbiotic archaeal growth and civilizational disease. Modern civilization results in changes in dietary habits leading to less consumption of fibre, stress and exposure to low level of EMF. This leads to increased colonic archaeal growth and archaeal endosymbiosis.Most diseases in the modern world are in a sense consequent to environmental change related archaeal endosymbiosis and are treatable only to a limited extend. This forms the basic biology of medical nihilism and the limits of human capability in medical interventions.