The book includes an introductory overview on the blood brain barrier, the normal structure of capillary wall, the material and the methods applied to the study of blood brain barrier, the increased vesicular and vacuolar transendothelial transport, the formation of transendothelial channels in traumatic human brain edema, the damage of endothelial junctions in perifocal human brain edema, the submicroscopic changes of cortical capillary pericytes in human traumatic brain edema, the ultrastructural alterations of human cortical capillary basement and glio-basement membrane union in perifocal brain edema, the perivascular astrocyte, oligodendroglial cell and microglial cell layer and the blood brain barrier disruption in traumatic brain injuries on aging human brain.