Grillner, Sten, MD.

The Brain in Motion

From Microcircuits to Global Brain Function

• Gebundenes Buch

Produktbeschreibung

"A complete and authoritative of the neural control of movement in animals ranging from lampreys to humans, including the roles of the cortex and basal ganglia, and will also cover motor disorders"--

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Produktdetails

• Verlag: MIT Press Ltd
• Seitenzahl: 286
• Erscheinungstermin: 31. Oktober 2023
• Englisch
• Abmessung: 152mm x 229mm x 21mm
• Gewicht: 470g
• ISBN-13: 9780262048200
• ISBN-10: 0262048205
• Artikelnr.: 68271067

Autorenporträt

Sten Grillner

Inhaltsangabe

Preface ix
1 THE VERTEBRATE MOTOR REPERTOIRE AND THE EVOLUTION
OF THE BRAIN 1
1.1 Introduction 1
1.2 Vertebrate Motor Behavior from Lamprey to Humans: Overview in an
Evolutionary Perspective 3
1.3 The Basic Building Blocks of Behavior: Motor Programs and Their
Selection—Overview 21
1.4 The Blueprint of the Vertebrate Motor System Is 500 Million Years Old
27
2 EXECUTION OF MOVEMENT: A PALETTE OF CPGS AND MOTOR
CENTERS FROM MIDBRAIN TO SPINAL CORD 39
2.1 Introduction 39
2.2 CPG Networks Producing Locomotor, Respiratory, and Chewing Movements
and Related Behaviors 40
2.3 A Brainstem Center for Coordination of Reaching and Grasping Movements
in the Lateral Reticular Medulla 66
2.4 The PAG Channels Commands from the Hypothalamus and Amygdala 71
2.5 Integration of Innate Motor Programs in Daily Life: Skilled Aspects of
the
Control of Motion 78
2.6 Conclusion 80con
3 THE VERTEBRATE SOLUTION FOR ACTION IN THE
EGOCENTRIC SPACE: MULTISENSORY INTEGRATION IN
THE TECTUM/SUPERIOR COLLICULUS 81
3.1 Introduction 81
3.2 Multisensory Representation of the Surrounding Space in the Tectum/SC
82
3.3 Tectum/SC Control of Eye, Orienting, and Evasive Movements 89
3.4 Conclusion 96
4 THE ROLES OF THE BASAL GANGLIA: FOR INITIATION OF
MOVEMENT AND MOTOR LEARNING 97
4.1 Overview: The Relation between the Cortex and the Basal Ganglia 97
4.2 Basal Ganglia: Organization 101
4.3 Synaptic Interaction within the Striatum 117
4.4 Integrated Function of the Basal Ganglia 127
4.5 Dysfunction of the Basal Ganglia: Parkinson’s and Huntington’s Diseases
and Other Conditions 143
4.6 The Contribution of the Basal Ganglia to the Selection of Action and
the
Control of Movement Amplitude 153
4.7 The Organization of the Basal Ganglia Is Conserved from Lampreys
to Primates 160
5 THE ROLE OF THE CORTEX IN THE CONTROL OF MOVEMENT 165
5.1 Introduction 165
5.2 Somatosensory and Visuomotor Coordination Critical in the Preparatory
Phase and the Transition between Diferent Commands in a
Motor Sequence 168
5.3 The Motor Areas in the Frontal Lobe of Primates and Other Vertebrates
175
5.4 Neocortical Organization at the Cellular Level and the Interaction
between
the Frontal Motor Areas, Striatum, and Downstream Motor Targets 189
5.5 Motor Capacity after Lesions to the Neocortex, Including the
Motor Cortex 197
5.6 Cortical Control of Robotic Arms via the Brain-Machine Interface after
Spinal Cord Injury 200
5.7 Concluding Remarks: The Neocortex and the Control of Movement 201
6 THE CEREBELLUM: CONTRIBUTES TO THE PERFECTION
OF COORDINATION 203
6.1 Introduction 203
6.2 The Cerebellar Circuitry 203
6.3 Spinal Cord Interaction with the Cerebellum: Locomotion and
Other Movements 210
6.4 The Cerebellum and the Vestibulo-Ocular and Optokinetic Reflexes:
Calibration of Motor Action 215
6.5 Parallel Fiber Synapses onto Purkinje Cells: Active and Silent
Synapses—
Plasticity 218
6.6 The Cerebellum’s Role for Learning to Associate Two Related but
Independent Processes: Conditioned Reflexes 219
6.7 Modeling and Simulation of the Cerebellar Circuitry 219
6.8 Concluding Remarks: The Overall Role of the Cerebellum 220
7 COMMENTS ON WHAT WE HAVE LEARNED AND
THE CHALLENGES AHEAD 223
7.1 “To Move or Not to Move,” a Question Answered by the Basal Ganglia
in Close Interaction with the Cortex 224
7.2 The Major Organizational Building Blocks of Motion 226
7.3 The Role of the Cerebellum: The Perfection of Coordination 226
7.4 Some Challenges Ahead 227
References 231
Index 261