The Brain Reward System

Herausgegeben:Fakhoury, Marc

• Gebundenes Buch

Produktbeschreibung

This volume explores the latest techniques used to better understand the brain reward system with respect to neurotransmitters, brain structures, and connectivity. This book aims to show readers tested laboratory protocols to study neural circuitry and biological processes implicated in reward, and in neuropsychiatric disorders such as substance use disorders. The chapters are organized into four parts. Part One addresses classical techniques to study the brain reward system, including the curve shift paradigm in intracranial self-stimulation, stereotaxic surgery in rodents, and the use of brain lesions. Part Two focuses on neurochemical, behavioral, and chemogenetic techniques such as immunofluorescence for assessing adult hippocampal neurogenesis, and fast-scan voltammetry. Part Three highlights methods used to assess the rewarding potential of drugs including intracranial self-stimulation combined with drug injection, and the use of viral vectors. The Fourth Part introduces imaging and electrophysiology techniques such as positron emission tomography, in vivo electrophysiology, and fiber photometry. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory.

Cutting-edge and thorough, The Brain Reward System is a valuable resource for researchers interested in learning more about the current methods used to study the delineation of the brain reward system.

Produktdetails

• Neuromethods 165
• Verlag: Humana / Springer US / Springer, Berlin
• Artikelnr. des Verlages: 978-1-0716-1145-6
• 1st ed. 2021
• Seitenzahl: 380
• Erscheinungstermin: 3. Dezember 2020
• Englisch
• Abmessung: 260mm x 183mm x 26mm
• Gewicht: 876g
• ISBN-13: 9781071611456
• ISBN-10: 1071611453
• Artikelnr.: 59893868

Inhaltsangabe

Intracranial Self-Stimulation and the Curve-Shift Paradigm: A Putative Model to Study the Brain Reward System.- Stereotaxic Surgery in Rodents for Stimulation of the Brain Reward System.- Characterizing the Neural Substrate of Reward with the Use of Specific Brain Lesions.- Assessment of Adult Hippocampal Neurogenesis: Implication for Neurodegenerative Diseases and Neurological Disorders.- Fast-Scan Voltammetry for In Vivo Measurements of Neurochemical Dynamics.- Carbon Fiber Probes for Real-Time Monitoring of Dopamine.- Immune-to-Brain Signaling Effects on the Neural Substrate for Reward: Behavioral Models of Aversion, Anhedonia, and Despair.- Behavioral Tests for Assessing Pain and Nociception: Relationship with the Brain Reward System.- Chemogenetic (DREADD) Exploration of Circuits Mediating Reward-Motivated Attention.- Intracranial Self-Stimulation: Using the Curve-Shift Paradigm to Assess the Abuse Potential of Drugs.- Drug Self-Administration as a Model to Study the Reward System.- Viral Vectors for Studying Drug-Seeking Behavior.- Conditioned Place Preference Test for Assessing the Rewarding Effects of Drugs of Abuse.- Positron Emission Tomography of the Reward System.- In Vivo Electrophysiology for Reward Anticipation and Processing.- Fiber Photometry of Neural Activity in Specific Neural Circuit.- Two-Photon Microscopy for Studying Reward Circuits of the Brain.