With extensive coverage of synthesis techniques and applications, this text describes chemical biology techniques which have gained significant impetus during the last five years. It focuses on the methods for obtaining modified and native nucleic acids, and their biological applications. Topics covered include: * chemical synthesis of modified RNA * expansion of the genetic alphabet in nucleic acids by creating new base pairs * chemical biology of DNA replication: probing DNA polymerase selectivity mechanisms with modified nucleotides * nucleic-acid-templated chemistry * chemical biology of…mehr
With extensive coverage of synthesis techniques and applications, this text describes chemical biology techniques which have gained significant impetus during the last five years. It focuses on the methods for obtaining modified and native nucleic acids, and their biological applications. Topics covered include: * chemical synthesis of modified RNA * expansion of the genetic alphabet in nucleic acids by creating new base pairs * chemical biology of DNA replication: probing DNA polymerase selectivity mechanisms with modified nucleotides * nucleic-acid-templated chemistry * chemical biology of peptide nucleic acids (PNA) * the interactions of small molecules with DNA and RNA * the architectural modules of folded RNAs * genesis and biological applications of locked nucleic acid (LNA) * small non-coding RNA in bacteria * microRNA-guided gene silencing * nucleic acids based therapies * innate immune recognition of nucleic acid * light-responsive nucleic acids for the spatiotemporal control of biological processes * DNA methylation * frameworks for programming RNA devices * RNA as a catalyst: The Diels-Alderase-Ribozyme * evolving an understanding of RNA function by in vitro approaches * the chemical biology of aptamers: synthesis and applications * nucleic acids as detection tools * bacterial riboswitch discovery and analysis The Chemical Biology of Nucleic Acids is an essential compendium of the synthesis of nucleic acids and their biological applications for bioorganic chemists, chemical biologists, medicinal chemists, cell biologists, and molecular biologists.Hinweis: Dieser Artikel kann nur an eine deutsche Lieferadresse ausgeliefert werden.
Günter Mayer, Assistant Professor, LIMES Prog. Unit Chemical Biology and Medicinal Chemistry, Kekulé-Institute for Organic Chemistry and Biochemistry, University of Bonn, Germany Professor Mayer's research involves molecular diversity applied to elucidate the conformation, function and identity of biomolecules. He is a co-founder of NascaCell Technologies AG, a leading service provider of innovative biomolecules, where he headed the combinatorial biotechnology department. He has published papers in leading journals such as Nature, Angewandte Chemie and Journal of the American Chemical Society.
Inhaltsangabe
Foreword vii Preface ix List of Contributors xi 1 Chemical Synthesis of Modified RNA 1 Claudia Höbartner and Falk Wachowius 2 Expansion of the Genetic Alphabet in Nucleic Acids by Creating New Base Pairs 39 Ichiro Hirao and Michiko Kimoto 3 Chemical Biology of DNA Replication: Probing DNA Polymerase Selectivity Mechanisms with Modified Nucleotides 63 Andreas Marx 4 Nucleic Acid-templated Chemistry 73 Michael Oberhuber 5 Chemical Biology of Peptide Nucleic Acids (PNAs) 103 Peter E. Nielsen 6 The Interactions of Small Molecules with DNA and RNA 115 Yun Xie, Victor K. Tam and Yitzhak Tor 7 The Architectural Motifs of Folded RNAs 141 Valérie Fritsch and Eric Westhof 8 Genesis and Biological Applications of Locked Nucleic Acids (LNAs) 175 Harleen Kaur and Souvik Maiti 9 Small Non-coding RNA in Bacteria 199 Sabine Brantl 10 MicroRNA-guided Gene Silencing 223 Gunter Meister 11 Nucleic Acid-based Therapies 233 Britta Hoehn and John J. Rossi 12 Innate Immune Recognition of Nucleic Acids 261 Stefan Bauer 13 Light-responsive Nucleic Acids for the Spatiotemporal Control of Biological Processes 279 Alexander Heckel and Günter Mayer 14 DNA Methylation 307 Albert Jeltsch and Renata Z. Jurkowska 15 Frameworks for Programming RNA Devices 323 Maung Nyan Win, Joe C. Liang and Christina D. Smolke 16 RNA as a Catalyst: The Diels-Alderase Ribozyme 339 Andres Jäschke 17 Evolving an Understanding of RNA Function by In Vitro Approaches 355 Qing Wang and Peter J. Unrau 18 The Chemical Biology of Aptamers: Synthesis and Applications 377 Günter Mayer and Bernhard Wulffen 19 Nucleic Acids as Detection Tools 401 Jeffrey C.F. Lam, Sergio Aguirre and Yingfu li 20 Bacterial Riboswitch Discovery and Analysis 433 Tyler D. Ames and Ronald R. Breaker Index 455
Foreword vii Preface ix List of Contributors xi 1 Chemical Synthesis of Modified RNA 1 Claudia Höbartner and Falk Wachowius 2 Expansion of the Genetic Alphabet in Nucleic Acids by Creating New Base Pairs 39 Ichiro Hirao and Michiko Kimoto 3 Chemical Biology of DNA Replication: Probing DNA Polymerase Selectivity Mechanisms with Modified Nucleotides 63 Andreas Marx 4 Nucleic Acid-templated Chemistry 73 Michael Oberhuber 5 Chemical Biology of Peptide Nucleic Acids (PNAs) 103 Peter E. Nielsen 6 The Interactions of Small Molecules with DNA and RNA 115 Yun Xie, Victor K. Tam and Yitzhak Tor 7 The Architectural Motifs of Folded RNAs 141 Valérie Fritsch and Eric Westhof 8 Genesis and Biological Applications of Locked Nucleic Acids (LNAs) 175 Harleen Kaur and Souvik Maiti 9 Small Non-coding RNA in Bacteria 199 Sabine Brantl 10 MicroRNA-guided Gene Silencing 223 Gunter Meister 11 Nucleic Acid-based Therapies 233 Britta Hoehn and John J. Rossi 12 Innate Immune Recognition of Nucleic Acids 261 Stefan Bauer 13 Light-responsive Nucleic Acids for the Spatiotemporal Control of Biological Processes 279 Alexander Heckel and Günter Mayer 14 DNA Methylation 307 Albert Jeltsch and Renata Z. Jurkowska 15 Frameworks for Programming RNA Devices 323 Maung Nyan Win, Joe C. Liang and Christina D. Smolke 16 RNA as a Catalyst: The Diels-Alderase Ribozyme 339 Andres Jäschke 17 Evolving an Understanding of RNA Function by In Vitro Approaches 355 Qing Wang and Peter J. Unrau 18 The Chemical Biology of Aptamers: Synthesis and Applications 377 Günter Mayer and Bernhard Wulffen 19 Nucleic Acids as Detection Tools 401 Jeffrey C.F. Lam, Sergio Aguirre and Yingfu li 20 Bacterial Riboswitch Discovery and Analysis 433 Tyler D. Ames and Ronald R. Breaker Index 455
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