The Concept of Endocannabinoid Signaling System in Cancer

The Concept of Endocannabinoid Signaling System in Cancer

An Emerging Target of Pharmacotherapy

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Endogenous arachidonic acid metabolites with properties similar to compounds of Cannabis sativa Linnaeus, the so-called Endocannabinoids, have effects on various types of cancer. The main active ingredient of cannabis, Delta9-tetrahydrocannabinol (Delta9-THC), produces its effects through activation of CB1 and CB2 receptors. CB1 receptors are expressed at high levels in the central nervous system (CNS), whereas CB2 receptors are concentrated predominantly, although not exclusively, in cells of the immune system. Although endocannabinoids and synthetic cannabinoids may have pro-proliferative ef...