Heavy metals, such as mercury (Hg), lead (Pb) and cadmium (Cd) are, widely known of being toxicants, also persistent organic pollutants, such as polychlorinated biphenyls (PCBs) and bisphenol-A (BPA), exposure have been attached to a variety of toxic effects in human. Therefore, the aim of the present work is to study the effect of persistent organic pollutants and toxic heavy metals and their contamination in any type of environmental pollution resulting from terrorist and military operations in three regions of Baghdad on thyroid gland and lipid profile in a sample of Iraqi individual from (AL-karradah and Abo-Gharib) groups compared with (AL-jadria) (control groups ). The correlation between the thyroid hormones thyroxine T4 , triiodothyronine T3, thyroid stimulating hormone (TSH), and thyroglobulin-antibodies(Tg-Ab) and the levels of Pb, Cd, Hg , (PCBs ) and (BPA) have been studied in the sera of the three studied groups. Seventy Five volunteers from three Iraqi areas were included in this study.