Introduction: Separation anxiety disorder (SAD) frequently affects prepubertal children and can have negative effects on their lives. Cognitive behavioral therapy (CBT) is essential for treating SAD, involving graded exposure and cognitive restructuring with parents. This study illustrates the clinical application of CBT.Methods: This study describes the CBT management of a 10-year-old girl with SAD at Mongi Slim Hospital (Tunis). Objectives included in vivo exposure, relaxation and readjustment of separation-related thoughts. The intervention aimed to reduce anxiety and reinforce the child's autonomy, with anxiety assessed before and after therapy.Results: Therapy reduced anxiety and improved the child's autonomy, enabling him to better manage separations and participate in social activities. Cognitive restructuring was necessary to address his excessive fears. Follow-up was suggested to maintain progress.Conclusion: CBT is an effective approach to treating SAD in children, as confirmed by recent literature.