Cynthia M Magro, A Neil Crowson, Martin C Mihm

The Cutaneous Lymphoid Proliferations

A Comprehensive Textbook of Lymphocytic Infiltrates of the Skin

• Gebundenes Buch

Produktbeschreibung

A masterful and thorough revision of the only single-source, authoritative reference on cutaneous lymphoproliferative disease. * Classic reference for unsurpassed coverage of lymphocytic infiltrates of the human skin * Covers a broad spectrum of topics ranging from the role of the immune system in the pathogenesis of cutaneous lymphocytic infiltrates to one describing the immunohistochemica nd molecular aspects of lymphoid neoplasia. * Each chapter contains an extensive array of 'clinical vignettes' clearly showing the application of principles and treatment techniques discussed in the chapter * Presents a succinct and logical approach to the diagnosis of most cutaneous lymphocytic infiltrates and discusses the interplay between the immune system in the propagation of lymphocytic infiltrates focusing on the role of iatrogenic and endogenous immune dysregulation. The molecular and cytogenetic basis of lymphoid neoplasia is considered in great detail. * Contains hundreds of full-color, high-quality clinical and histologic photographs, with over 200 new images in the new edition

Produktdetails

• Verlag: John Wiley & Sons / Wiley
• 2nd Revised edition
• Seitenzahl: 568
• Erscheinungstermin: 23. Februar 2016
• Englisch
• Abmessung: 282mm x 216mm x 33mm
• Gewicht: 1801g
• ISBN-13: 9781118776261
• ISBN-10: 1118776267
• Artikelnr.: 43043559

Autorenporträt

Cynthia M. Magro MD Professor of Pathology and Laboratory Medicine Department of Pathology, Cornell University Weill Cornell Medicine New York, NY, USA A. Neil Crowson MD Clinical Professor of Dermatology, Pathology, and Surgery Director of Dermatopathology at the University of Oklahoma and Regional Medical Laboratory President of Pathology Laboratory Associates Tulsa, OK, USA Martin C. Mihm MD Clinical Professor of Pathology and Dermatology, Harvard Medical School Director of Melanoma Program, Dermatology, Brigham and Women's Hospital Co-Director of Melanoma Program, Dana-Farber and Brigham and Women's Cancer Center Director, Mihm Cutaneous Pathology Consultative Service Brigham and Women's Hospital Boston, MA, USA

Inhaltsangabe

Acknowledgments, viii 1 Introduction to the Classification of Lymphoma 1
Kiel Lukes-Collins, and Working Formulation classifications 1 WHO, REAL,
EORTC, and the Combined WHO/EORTC classifications 2 Summary 7 References 8
Appendix: Definitions of key terms and techniques 9 2 The Therapy of
Cutaneous T Cell Lymphoma 14 Benjamin H. Kaffenberger, Mark A. Bechtel, and
Pierluigi Porcu Introduction 14 Diagnostic work-up and staging procedures
14 CTCL therapies 15 Goals of therapy in advanced-stage CTCL 16
Extracorporeal photopheresis (ECP) 17 Interferons 17 Retinoids 17
Immunotoxins 18 Monoclonal antibodies 18 Histone deacetylase inhibitors
(HDACi) 19 Antibody drug conjugates (ADC) 19 Cytotoxic chemotherapy 19
Investigational therapies 20 TLR agonists and cytokines 20 Allogeneic
hematopoietic stem cell transplantation (allo-HSCT) 20 References 21 3
Molecular Analysis in Cutaneous Lymphoid Proliferation 23 Shabnam Momtahen,
Cynthia Magro, and Carl Morrison Introduction 23 Immunoglobulin and T cell
receptor structure 23 PCR design for determination of clonality 24
Detection of PCR products for clonality 24 Evaluation of results 25 The
value and utility of molecular diagnostics in primary cutaneous lymphomas
26 Limitations of clonality assessment by PCR 27 Case vignettes 29
References 36 4 Benign Lymphocytic Infiltrates 37 Introduction 37
Spongiotic and eczematous dermatitis 37 Other spongiotic/eczematous tissue
reactions 40 Other causes of subacute eczematous dermatitis 40 Interface
dermatitis: cell-poor vacuolar interface dermatitis 42 Interface
dermatitis: lichenoid pattern 46 Diffuse and nodular lymphocytic dermal
infiltrates without atypia 51 Diffuse and nodular lymphocytic infiltrates
associated with autoimmune disease 53 References 57 5 Reactive Lymphomatoid
Tissue Reactions Mimicking Cutaneous T and B Cell Lymphoma 59 Lymphomatoid
drug eruptions 59 Molecular profile of lymphomatoid drug eruptions 61
Pathogenetic basis of lymphomatoid drug reactions 62 Reactive lymphomatoid
lesions encountered in lesions of collagen vascular disease 63 Angiomatous
Variants of Pseudolymphoma 67 Case vignettes 69 References 86 6 Precursor
Lesions of Cutaneous T Cell Lymphoma 89 Cutaneous T cell lymphoid dyscrasia
89 Large plaque parapsoriasis 90 Hypopigmented interface T cell dyscrasia:
a unique indolent T cell dyscrasia 91 Pigmented purpuric dermatosis (PPD)
92 Pityriasis lichenoides 94 Idiopathic erythroderma (pre-Sézary) 96
Syringolymphoid hyperplasia with alopecia 96 Folliculotropic T cell
lymphocytosis/pilotropic T cell dyscrasia 97 Idiopathic follicular
mucinosis/alopecia mucinosa 98 Keratoderma-like T cell dyscrasia 99
Atypical lymphocytic lobular panniculitis 100 Case vignettes 102 References
132 7 Marginal Zone Lymphoma and Other Related Post Germinal Center B Cell
Lymphoproliferative Disorders of The Skin 134 Marginal zone lymphoma 134
Blastic marginal zone lymphoma 140 Epidermotropic marginal zone lymphoma
140 Castleman disease 141 Primary cutaneous plasmacytoma 142 Case vignettes
145 References 166 8 Primary Cutaneous Follicle Center Cell Lymphoma 169
Clinical features 169 Pathology 169 Phenotypic profile 171 Molecular
studies 172 Pathogenesis 172 Cytogenetics 172 Case vignettes 174 Additional
molecular and cytogenetic study 185 References 186 9 Primary Cutaneous
Diffuse Large B-Cell Lymphoma Including the Leg Type and Precursor B Cell
Lymphoblastic Lymphoma 187 Primary cutaneous diffuse large B cell lymphoma
187 Systemic diffuse large B cell lymphomas with a propensity to involve
the skin 197 Case vignettes 200 Additional light microscopic, phenotypic,
molecular, cytogenetic studies 210 References 215 10 Intravascular Lymphoma
218 Clinical features 218 Light microscopic findings 219 Phenotypic profile
219 Molecular and cytogenetic studies 219 Pathogenesis 219 Differential
diagnosis 219 Intravascular anaplastic large cell lymphoma 219 Benign
intravascular proliferations of histiocytes and reactive T cells 220 Case
vignettes 221 References 224 11 Cutaneous Mantle Cell Lymphoma 225 Clinical
features 225 Light microscopic findings 225 Phenotypic profile 226
Molecular studies 227 Cytogenetic profile 227 Pathogenesis 227 Case
vignettes 229 Additional molecular and cytogenetic studies 233 References
234 12 Mycosis Fungoides and Sézary Syndrome 236 Definition 236 Mycosis
fungoides 236 Sézary syndrome and erythrodermic mycosis fungoides 243 Large
cell transformation of mycosis fungoides 251 Extracutaneous involvement in
mycosis fungoides 254 Case vignettes 259 References 271 13 CD30-Positive
Lymphoproliferative Disorders Including Lymphomatoid Papulosis, Borderline
CD30-Positive Lymphoproliferative Disease, Anaplastic Large Cell Lymphoma,
and T-Cell-Rich CD30-Positive Large B Cell Lymphoma 274 Introduction 274
Lymphomatoid papulosis 274 CD8+ lymphomatoid papulosis, including the type
D variant 278 Type E lymphomatoid papulosis (Case vignette 15) 278
Borderline CD30-positive lymphoproliferative disorders (type C LYP) (Case
vignette 9) 279 Lymphomatoid papulosis with a rearrangement of chromosome
6p25.3 279 Cutaneous anaplastic large cell lymphoma 280 Small cell ALCL 282
Additional unusual histologic variants of anaplastic large cell lymphoma
282 Breast-implant-associated anaplastic large cell lymphoma 282
Intravascular anaplastic large cell lymphoma 282 Sarcomatoid anaplastic
large cell lymphoma (Case vignette 14) 283 CD30-positive large B cell
lymphoma 285 Case vignettes 286 References 309 14 CD4+ Peripheral T Cell
Lymphoma, Not Otherwise Specified, Including Primary Cutaneous Cd4+
Small/Medium-Sized Pleomorphic T Cell Lymphoma 312 Introduction 312 Primary
cutaneous CD4+ small/medium-sized pleomorphic T cell lymphoma 312
CD30-negative large cell T cell lymphoma 313 Cutaneous follicular helper T
cell lymphoma 314 Overview of overall prognosis of primary cutaneous
peripheral T cell lymphoma, unspecified 315 Evolution of the nomenclature
of primary cutaneous CD4+ small/medium-sized pleomorphic T cell lymphoma
319 Case vignettes 320 References 333 15 Subcutaneous Panniculitis-Like T
Cell Lymphoma 334 Clinical features 334 Morphology 336 Phenotype 337
Molecular studies 337 Differential diagnosis 337 Case vignettes 340
References 349 16 CD8 T Cell Lymphoproliferative Disease of the Skin 351
Overview 351 Introduction 351 Classification of primary CD8+ cutaneous T
cell lymphomas 352 Histomorphology of primary cutaneous CD8+ T cell
lymphoma: primary cutaneous aggressive epidermotropic CD8+ T cell lymphoma,
and CD8+ variants of peripheral T cell lymphoma, NOS, including primary
cutaneous CD8+ granulomatous T cell lymphoma 353 CD8 variant of
lymphomatoid papulosis and other related CD30-positive T cell
lymphoproliferative disorders of CD8 subtype 354 Light microscopic findings
354 Indolent CD8 positive lymphoid proliferation of the face and other body
sites including acral surfaces 355 CD8 prolymphocytic leukemia 355 CD8
pseudolymphoma related to underlying HIV disease 356 Drug-associated CD8+
pseudolymphoma 356 Actinic reticuloid as a unique form of
CD8+pseudolymphoma 356 Case vignettes 357 References 375 17 Nasal and
Related Extranodal Natural Killer Cell/T Cell Lymphomas and Blastic
Plasmacytoid Dendritic Cell Neoplasm 377 Introduction 377 Biology of NK and
NK-like T cells 377 NK/T-cell lymphoma 379 Nasal NK/T cell lymphoma 379
Nasal type NK/T cell lymphoma 380 Aggressive NK cell lymphoma 380 Role of
Epstein-Barr virus in the evolution of NK/T cell lymphomas 382 Blastic
plasmacytoid dendritic cell neoplasm 382 CD56-positive gamma delta lymphoma
involving the subcutaneous fat 383 Chronic granular lymphocytosis/large
granular cell leukemia 384 Natural killer-like CD4+ T cell lymphoma 384
EBV-associated NK/T cell lymphomas of the elderly 385 Hydroa vaccineforme
(HV)-like lymphoma 385 Cutaneous intravascular NK T cell lymphoma 386 Case
vignettes 387 References 401 18 Primary Cutaneous gamma delta T Cell
Lymphoma 404 Introduction 404 Case vignettes 409 Additional supplemental
figures 411 References 414 19 Epstein-Barr Virus-Associated
Lymphoproliferative Disease 415 Introduction 415 Hydroa vacciniforme-like
EBV-associated T cell lymphoproliferative disease/mosquito bite
hypersensitivity 416 EBV+ cutaneous B cell lymphoproliferative disorder of
the elderly 420 EBV-associated mucocutaneous ulcer 421 EBV + T cell
lymphoproliferative disease of the elderly 421 General principles regarding
EBV-associated lymphomagenesis 421 Pathogenetic link between EBV-associated
B cell lymphoma and iatrogenic immune dysregulation related to either
methotrexate or cyclosporine 421 Case vignettes 423 References 432 20
Hodgkin Lymphoma of the Skin 435 Clinical features 435 Subtypes of Hodgkin
lymphoma 436 References 447 21 Chronic Lymphocytic Leukemia of B Cell and T
Cell Prolymphocytic Leukemia 449 B cell chronic lymphocytic leukemia 449 T
cell prolymphocytic leukemia 452 Case vignettes 455 References 471 22 Adult
T Cell Leukemia/Lymphoma 473 Clinical features 473 Pathology 474 Phenotypic
studies 475 Pathogenesis 475 Infective dermatitis of childhood 476 Case
vignettes 477 References 484 23 Angioimmunoblastic
Lymphadenopathy/Angioimmunoblastic T Cell Lymphoma 486 Clinical features
486 Light microscopic findings 487 Phenotypic studies 488 Molecular studies
488 Pathogenesis 489 Case vignettes 491 References 497 24 Lymphomatoid
Granulomatosis 499 Introduction 499 Clinical features 499 Histopathology
500 Histogenesis 501 Clonality studies 501 Differential diagnosis 501
Treatment 502 Case vignette 503 References 506 25 Cutaneous Infiltrates of
Myeloid Derivation 507 Introduction 507 Leukemia cutis 507 Clonal
histiocytopathy syndromes 509 Histiocytopathy of factor XIIIA perivascular
dermal dendritic cell origin 514 Case vignettes 517 References 537 Index
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