Annual Report on Medicinal Chemistry series, highlights new advances in the field with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.
Annual Report on Medicinal Chemistry series, highlights new advances in the field with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.
Richard A. Ward is at AstraZeneca, UKNeil Grimster is at AstraZeneca, USA
Inhaltsangabe
Preface Richard Andrew Ward and Neil Grimster 1. The history of covalent inhibitors Renato A. Bauer 2. Kinetic Mechanisms of Covalent Inhibition Claire Louise McWhirter 3. Covalent Drugs in Development for Immune-Mediated Diseases Leonard Sung 4. Chemistry Perspectives of Reversible Covalent Drugs Jianmin Gao 5. Design of Next-Generation Covalent Inhibitors: Targeting Residues Beyond Cysteine Lyn Jones 6. Boron and Covalent Inhibition Andrew Leach 7. Measuring and predicting warhead and residue reactivity Christopher Rowley 8. Computational Support of Structure-based Targeted Covalent Inhibitor Design Robert Abel 9. Novel approaches to covalent inhibition Nir London 10. The future of covalent inhibition Gyorgy M. Keseru
Preface Richard Andrew Ward and Neil Grimster 1. The history of covalent inhibitors Renato A. Bauer 2. Kinetic Mechanisms of Covalent Inhibition Claire Louise McWhirter 3. Covalent Drugs in Development for Immune-Mediated Diseases Leonard Sung 4. Chemistry Perspectives of Reversible Covalent Drugs Jianmin Gao 5. Design of Next-Generation Covalent Inhibitors: Targeting Residues Beyond Cysteine Lyn Jones 6. Boron and Covalent Inhibition Andrew Leach 7. Measuring and predicting warhead and residue reactivity Christopher Rowley 8. Computational Support of Structure-based Targeted Covalent Inhibitor Design Robert Abel 9. Novel approaches to covalent inhibition Nir London 10. The future of covalent inhibition Gyorgy M. Keseru
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