The Digital Patient
Advancing Healthcare, Research, and Education
Herausgeber: Combs, C D; Banks, Catherine M; Sokolowski, John A
The Digital Patient
Advancing Healthcare, Research, and Education
Herausgeber: Combs, C D; Banks, Catherine M; Sokolowski, John A
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A modern guide to computational models and constructive simulation for personalized patient care using the Digital Patient The healthcare industry's emphasis is shifting from merely reacting to disease to preventing disease and promoting wellness. Addressing one of the more hopeful Big Data undertakings, The Digital Patient: Advancing Healthcare, Research, and Education presents a timely resource on the construction and deployment of the Digital Patient and its effects on healthcare, research, and education. The Digital Patient will not be constructed based solely on new information from all…mehr
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- Produktdetails
- Verlag: John Wiley & Sons / Wiley
- Seitenzahl: 336
- Erscheinungstermin: 11. Januar 2016
- Englisch
- Abmessung: 251mm x 178mm x 20mm
- Gewicht: 567g
- ISBN-13: 9781118952757
- ISBN-10: 1118952758
- Artikelnr.: 43115237
- Verlag: John Wiley & Sons / Wiley
- Seitenzahl: 336
- Erscheinungstermin: 11. Januar 2016
- Englisch
- Abmessung: 251mm x 178mm x 20mm
- Gewicht: 567g
- ISBN-13: 9781118952757
- ISBN-10: 1118952758
- Artikelnr.: 43115237
Development
Education
and Healthcare Practice 1 1 The Digital Patient 3 C. Donald Combs Health
The Goal
4 Personalized Medicine
4 The Best Outcomes
5 The Emergence of the Digital Patient
5 The Human Physiome
6 Enabling the Digital Patient
8 P4 Medicine
11 Conclusion
11 References
12 2 Reflecting on Discipulus and Remaining Challenges 15 Vanessa Díaz?]Zuccarini
Mona Alimohammadi
and César Pichardo?]Almarza Introduction
15 A Brief Contextual Background and a Call for Integration: Personalized Medicine is Holistic
16 The Many Versions of the Digital Patient: On the Road to Medical Avatars
18 Discipulus: The Digital Patient Technological Challenges and Main Conclusions
19 The Remaining Challenges and Big Data
24 Conclusion
25 References
26 3 Advancing the Digital Patient 27 Catherine M. Banks Introduction
27 The Digital Patient: Its Early Start
28 Engaging the Digital Patient
30 Conclusion
31 4 The Significance of Modeling and Visualization 33 John A. Sokolowski and Hector M. Garcia Introduction
33 Modeling a Complex System: Human Physiology
34 Medical Modeling
Simulation
and Visualization
35 Modes and Types of Visualization
40 Visualization for Patient?]Specific Usefulness
43 Conclusion
43 References
45 Part 2 State of the Art: Systems Biology
the Physiome and Personalized Health 49 5 The Visible Human: A Graphical Interface for Holistic Modeling and Simulation 51 Victor M. Spitzer Introduction
51 Education
53 Modeling
55 Virtual Reality Trainers and Simulators
56 Conclusion
58 References
59 6 The Quantifiable Self: Petabyte by Petabyte 63 C. Donald Combs and Scarlett R. Barham Introduction
63 Smarr's Quantified Self
64 Extending Smarr's Research
67 The Quantified Self?]Vision
Simplified
69 Criticism
69 Conclusion
71 References
72 7 Systems Biology and Health Systems Complexity: Implications for the Digital Patient 73 C. Donald Combs
Scarlett R. Barham
and Peter M. A. Sloot Introduction
73 Systems Biology
75 The Institute for Systems Biology
76 The Complexity Institute
78 The Potential of Systems Biology
81 Criticism
82 Conclusion
83 References
83 8 Personalized Computational Modeling for the Treatment of Cardiac Arrhythmias 85 Seth H. Weinberg Introduction
85 Basics of Cardiac Electrophysiology
86 Cardiac Modeling Advancements
89 Regulation of Intracellular Calcium
90 From Cells to Cables to Sheets to Tissue to the Heart
91 Where Can we go from Here? What is the Cardiac Model in the Digital Patient? 95 References
96 9 The Physiome Project
openEHR Archetypes
and the Digital Patient 101 David P. Nickerson
Koray Atalag
Bernard de Bono
and Peter J. Hunter Introduction
101 Multiscale Physiological Processes
102 Physiome Project Standards
Repositories
and Tools
103 Archetype Specialization
112 Archetype Definition Language
113 Linking Archetypes to External Knowledge Sources (Terminology and Biomedical Ontologies)
114 Archetype Annotations
114 OpenEHR Model Repository and Governance
115 Fast Healthcare Interoperability Resources
115 A Disease Scenario
116 Summary and Conclusions
121 References
122 10 Physics?]Based Modeling for the Physiome 127 William A. Pruett and Robert L. Hester Introduction
127 Modeling Schemes
128 Future Challenges
142 Conclusion
142 Acknowledgments
143 References
143 11 Modeling and Understanding the Human Body with SwarmScript 149 Sebastian von Mammen
Stefan Schellmoser
Christian Jacob
and Jörg Hähner Introduction
149 Related Work
150 Multiagent Organization
152 Designing Interactive Agents
152 Speaking SwarmScript
153 Answering Demand: The Design of SwarmScript
153 Graph?]Based Rule Representation
153 The Source-Action-Target
154 SwarmScript INTO3D
154 A SwarmScript Dialogue
155 Discussion
159 Summary
161 References
162 12 Using Avatars and Agents to Promote Real?]World Health Behavior Changes 167 Sun Joo (Grace) Ahn Introduction
167 Avatars and Agents
168 Using Agents and Avatars to Promote Health Behavior Changes
169 Conclusion
174 References
174 13 Virtual Reality and Eating
Diabetes
and Obesity 179 Jessica E. Cornick and Jim Blascovich Introduction
179 Virtual Reality
179 Obesity and Weight Stigma
184 Virtual Reality as a Tool for Combatting Health Issues
185 Conclusion
189 References
189 14 Immersive Virtual Reality to Model Physical: Social Interaction and Self?]Representation 197 Eric B. Bauman Introduction
197 Theory for Immersive Virtual Learning Spaces
197 Conclusion
202 References
203 Part 3 Challenges: Assimilating the Comprehensive Digital Patient 205 15 A Roadmap for Building a Digital Patient System 207 Saikou Y. Diallo and Christopher J. Lynch Introduction
207 Approach
210 Building the Digital Patient Through Interoperability
211 Conclusion
221 Acknowledgments
221 References
221 16 Multidisciplinary
Interdisciplinary
and Transdisciplinary Research: Contextualization and Reliability of the Composite 225 Andreas Tolk Introduction
225 Interdisciplinarity and Interdisciplinary Research
226 Data Engineering to Support Interdisciplinarity and Interoperability
228 Base Object Models to Support Transdisciplinarity and Composability
233 Open Challenges on Reliability
235 Summary and Conclusion
237 References
239 17 Bayes Net Modeling: The Means to Craft the Digital Patient 241 Joseph A. Tatman and Barry C. Ezell Introduction
241 Other Interesting Applications
246 Conclusion
251 References
253 Part 4 Potential Impact: Engaging The Digital Patient 255 18 Virtual Reality Standardized Patients for Clinical Training 257 Albert Rizzo and Thomas Talbot Introduction
257 The Rationale for Virtual Standardized Patients
258 Conversational Virtual Human Agents
259 Usc Efforts to Create Virtual Standardized Patients
260 Conclusion
269 References
270 19 The Digital Patient: Changing the Paradigm of Healthcare and Impacting Medical Research and Education 273 V. Andrea Parodi Introduction
273 Overview Digital Medicine Projects
275 Personalized Patient Care Clinical Use
279 Recommended Education and Training for VPH Project Participation
281 From Flexner to the 2010 Carnegie Report
284 Summary Statements
286 References
287 20 The Digital Patient: A Vision for Revolutionizing the Electronic Medical Record and Future Healthcare 289 Richard M. Satava Introduction
289 Applications of the Digital Patient as the EMR
291 Discussion
296 Conclusion
297 References
297 21 Realizing the Digital Patient 299 C. Donald Combs and John A. Sokolowski Index 305
Development
Education
and Healthcare Practice 1 1 The Digital Patient 3 C. Donald Combs Health
The Goal
4 Personalized Medicine
4 The Best Outcomes
5 The Emergence of the Digital Patient
5 The Human Physiome
6 Enabling the Digital Patient
8 P4 Medicine
11 Conclusion
11 References
12 2 Reflecting on Discipulus and Remaining Challenges 15 Vanessa Díaz?]Zuccarini
Mona Alimohammadi
and César Pichardo?]Almarza Introduction
15 A Brief Contextual Background and a Call for Integration: Personalized Medicine is Holistic
16 The Many Versions of the Digital Patient: On the Road to Medical Avatars
18 Discipulus: The Digital Patient Technological Challenges and Main Conclusions
19 The Remaining Challenges and Big Data
24 Conclusion
25 References
26 3 Advancing the Digital Patient 27 Catherine M. Banks Introduction
27 The Digital Patient: Its Early Start
28 Engaging the Digital Patient
30 Conclusion
31 4 The Significance of Modeling and Visualization 33 John A. Sokolowski and Hector M. Garcia Introduction
33 Modeling a Complex System: Human Physiology
34 Medical Modeling
Simulation
and Visualization
35 Modes and Types of Visualization
40 Visualization for Patient?]Specific Usefulness
43 Conclusion
43 References
45 Part 2 State of the Art: Systems Biology
the Physiome and Personalized Health 49 5 The Visible Human: A Graphical Interface for Holistic Modeling and Simulation 51 Victor M. Spitzer Introduction
51 Education
53 Modeling
55 Virtual Reality Trainers and Simulators
56 Conclusion
58 References
59 6 The Quantifiable Self: Petabyte by Petabyte 63 C. Donald Combs and Scarlett R. Barham Introduction
63 Smarr's Quantified Self
64 Extending Smarr's Research
67 The Quantified Self?]Vision
Simplified
69 Criticism
69 Conclusion
71 References
72 7 Systems Biology and Health Systems Complexity: Implications for the Digital Patient 73 C. Donald Combs
Scarlett R. Barham
and Peter M. A. Sloot Introduction
73 Systems Biology
75 The Institute for Systems Biology
76 The Complexity Institute
78 The Potential of Systems Biology
81 Criticism
82 Conclusion
83 References
83 8 Personalized Computational Modeling for the Treatment of Cardiac Arrhythmias 85 Seth H. Weinberg Introduction
85 Basics of Cardiac Electrophysiology
86 Cardiac Modeling Advancements
89 Regulation of Intracellular Calcium
90 From Cells to Cables to Sheets to Tissue to the Heart
91 Where Can we go from Here? What is the Cardiac Model in the Digital Patient? 95 References
96 9 The Physiome Project
openEHR Archetypes
and the Digital Patient 101 David P. Nickerson
Koray Atalag
Bernard de Bono
and Peter J. Hunter Introduction
101 Multiscale Physiological Processes
102 Physiome Project Standards
Repositories
and Tools
103 Archetype Specialization
112 Archetype Definition Language
113 Linking Archetypes to External Knowledge Sources (Terminology and Biomedical Ontologies)
114 Archetype Annotations
114 OpenEHR Model Repository and Governance
115 Fast Healthcare Interoperability Resources
115 A Disease Scenario
116 Summary and Conclusions
121 References
122 10 Physics?]Based Modeling for the Physiome 127 William A. Pruett and Robert L. Hester Introduction
127 Modeling Schemes
128 Future Challenges
142 Conclusion
142 Acknowledgments
143 References
143 11 Modeling and Understanding the Human Body with SwarmScript 149 Sebastian von Mammen
Stefan Schellmoser
Christian Jacob
and Jörg Hähner Introduction
149 Related Work
150 Multiagent Organization
152 Designing Interactive Agents
152 Speaking SwarmScript
153 Answering Demand: The Design of SwarmScript
153 Graph?]Based Rule Representation
153 The Source-Action-Target
154 SwarmScript INTO3D
154 A SwarmScript Dialogue
155 Discussion
159 Summary
161 References
162 12 Using Avatars and Agents to Promote Real?]World Health Behavior Changes 167 Sun Joo (Grace) Ahn Introduction
167 Avatars and Agents
168 Using Agents and Avatars to Promote Health Behavior Changes
169 Conclusion
174 References
174 13 Virtual Reality and Eating
Diabetes
and Obesity 179 Jessica E. Cornick and Jim Blascovich Introduction
179 Virtual Reality
179 Obesity and Weight Stigma
184 Virtual Reality as a Tool for Combatting Health Issues
185 Conclusion
189 References
189 14 Immersive Virtual Reality to Model Physical: Social Interaction and Self?]Representation 197 Eric B. Bauman Introduction
197 Theory for Immersive Virtual Learning Spaces
197 Conclusion
202 References
203 Part 3 Challenges: Assimilating the Comprehensive Digital Patient 205 15 A Roadmap for Building a Digital Patient System 207 Saikou Y. Diallo and Christopher J. Lynch Introduction
207 Approach
210 Building the Digital Patient Through Interoperability
211 Conclusion
221 Acknowledgments
221 References
221 16 Multidisciplinary
Interdisciplinary
and Transdisciplinary Research: Contextualization and Reliability of the Composite 225 Andreas Tolk Introduction
225 Interdisciplinarity and Interdisciplinary Research
226 Data Engineering to Support Interdisciplinarity and Interoperability
228 Base Object Models to Support Transdisciplinarity and Composability
233 Open Challenges on Reliability
235 Summary and Conclusion
237 References
239 17 Bayes Net Modeling: The Means to Craft the Digital Patient 241 Joseph A. Tatman and Barry C. Ezell Introduction
241 Other Interesting Applications
246 Conclusion
251 References
253 Part 4 Potential Impact: Engaging The Digital Patient 255 18 Virtual Reality Standardized Patients for Clinical Training 257 Albert Rizzo and Thomas Talbot Introduction
257 The Rationale for Virtual Standardized Patients
258 Conversational Virtual Human Agents
259 Usc Efforts to Create Virtual Standardized Patients
260 Conclusion
269 References
270 19 The Digital Patient: Changing the Paradigm of Healthcare and Impacting Medical Research and Education 273 V. Andrea Parodi Introduction
273 Overview Digital Medicine Projects
275 Personalized Patient Care Clinical Use
279 Recommended Education and Training for VPH Project Participation
281 From Flexner to the 2010 Carnegie Report
284 Summary Statements
286 References
287 20 The Digital Patient: A Vision for Revolutionizing the Electronic Medical Record and Future Healthcare 289 Richard M. Satava Introduction
289 Applications of the Digital Patient as the EMR
291 Discussion
296 Conclusion
297 References
297 21 Realizing the Digital Patient 299 C. Donald Combs and John A. Sokolowski Index 305