The general objective of this study is to analyze the effect of domestic savings on banking stress in the UEMOA zone. To achieve our objective, we used a dataset from a sample of 7 UEMOA countries except Guinea-Bissau, covering the period 1996-2020. Using the Pooled Mean Group (PMG) estimator, the results revealed that savings exert a positive effect on banking stress in the short term, while in the long term, its effect is negative. On the other hand, inflation has a positive effect on long-term banking stress, while bank size and GDP growth rate both have a negative effect on long-term banking stress.Keywords: Banking stress, domestic savings, PMG, UEMOA.