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Sexual desire is a motivational (psychological) state in which an interest, wish or drive to seek out or engage in sexual activities. Some studies reported that khat has an effect on sexual desire. However, the effect of khat chewing on sexual desire (Weather increased, decreased or remain the same) is not well recognized due to the absence of adequate studies in our country and other countries. The Objective of the study was to assess the effect of khat chewing on sexual desire among adults in Logia town, North East Ethiopia. A comparative cross-sectional study design was conducted from March 2016 to June 2016 in Logia town. A total of three hundred thirty four study subjects both males and females aged 18-49 years were included in the study.