HSC is the network created through the flow of services, supplies, information and finances between donors, beneficiaries, suppliers and different units of HAO, in order to provide physical aid to beneficiaries. Both the number of natural and man-made challenges and the people affected by these challenges have increased substantially during the recent decades. There exists a limited body of empirical research within the field of HSC and this study is presented to address this limitation by utilizing an operations research. The findings show that each dimension of SCM challenges has a negative effect on responsiveness, collaboration, flexibility and cost performances.Finally this study recommends that, it is advisable to closely working and collaboration with different partners and stakeholders is extremely essential to minimize the SCM challenges, and ensure service quality and sustainability.Therefore, this study is expected to fill the empirical gap in literature on effects of supply chain management challenges on the humanitarian aid organization, which need to be bridged to ensure that humanitarian supply chains are improved and managed on the basis of informed evidence.