The term ischemic heart disease (IHD) defines a disease spectrum of diverse etiology, with the common factor being an imbalance between myocardial oxygen supply and demand Clinical expression of ischemic heart disease (IHD) falls into the following groups: stable chronic angina, acute syndrome encompassing unstable angina, acute myocardial infarction (AMI), and sudden ischemic death. The production of free radicals and lipid peroxidation during the course of acute attack of ischemic heart disease may be a key feature, and hence important, of disease development. In this study an attempted is made to shed a light on the possible relationships between lipid peroxidation marker, serum malondialdehyde (MDA), and the traditional biomarkers used for the diagnosis and evaluation of the IHD serum level of the lipid profile, total cholesterol, triglycerides, HDLc, LDLc and VLDLc. Serum levels of the trace elements: zinc and calcium, zinc was evaluated and also correlated with the lipid peroxidation parameter, serum MDA and LDL. The serum level of Vitamin E ( -TOH) as an antioxidant, was correlated with MDA.