The economic trajectory of Ghana has been notably dynamic in recent years, consistently ranking among the top ten fastest-growing economies in Africa since 2017. However, the year 2020 brought unprecedented challenges, as plummeting oil prices and the onset of the COVID-19 pandemic precipitated a significant economic downturn, plunging the nation into recession. Through this analytical lens, this book was able to unravel the intricate interplay of diverse socio-economic factors and their respective contributions to the observed patterns of unemployment amid the COVID-19 crisis. Notably, this book reveals that the burgeoning financial burdens stemming from unemployment, coupled with the pervasive apprehension surrounding job security, collectively exert upward pressure on the national public debt. By foregrounding these hitherto underexplored dimensions, the study advances our understanding of the nuanced determinants of unemployment amid the COVID-19 crisis, thereby offering valuable insights for policymakers, researchers, and practitioners alike.