Academic stress is notable among undergraduates and this often leads to negative consequences. Previous studies had focused on the determinants of academic stress among secondary school students with little consideration for undergraduates. This study, therefore, determined the effects of Emotional Coaching Technique (ECT) and Interpersonal Psychotherapy (IP) in the management of undergraduates' academic stress in the South-West, Nigeria. The moderating effects of gender and self-efficacy were examined.The cognitive appraisal theory provided the framework for the study, while the pretest-posttest, control group quasi experimental design with 3x2x3 factorial matrix was adopted. Multistage sampling technique was used. Three federal universities: University of Ibadan, Ibadan (UI), Obafemi Awolowo University, Ile-Ife (OAU) and Federal University of Agriculture, Abeokuta (FUNAAB) were randomly selected. One hundred and three participants across the three universities who scored 40.0% and above out of 100.0% in the screening exercise, were recruited for the study. They were randomly assigned to ECT, IP and the Control groups.