The Effects of Lactobacillus Reuteri in Diabetic Rats - Nourazarian, Seyed-Manuchehr;Dolatkhah, Homayun;Nourazarian, Ali-Reza
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Renal failure caused by diabetes mellitus , called the diabetic nephropathy (DN), is a serious health problem in the world. Identifying molecular mechanism of the pathogenesis of DN may be helpful in developing new therapeutics. Oxidative stress in mesangial cell caused by hyperglycemia is closely related to the development of DN.BMP-7 helps to maintain renal functions and structural integrity,This molecule, however, disappear early during diabetic nephropathy progression.This study aims to investigate : the effects of lactobacillus reuteri PTCC1655 on serum levels of -SMA,PAI-1, Nitric oxide…mehr

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Produktbeschreibung
Renal failure caused by diabetes mellitus , called the diabetic nephropathy (DN), is a serious health problem in the world. Identifying molecular mechanism of the pathogenesis of DN may be helpful in developing new therapeutics. Oxidative stress in mesangial cell caused by hyperglycemia is closely related to the development of DN.BMP-7 helps to maintain renal functions and structural integrity,This molecule, however, disappear early during diabetic nephropathy progression.This study aims to investigate : the effects of lactobacillus reuteri PTCC1655 on serum levels of -SMA,PAI-1, Nitric oxide and tissue gene expression levels of TGF-betaand BMP-7 as factors involved in renal fibrosis in streptozodotocin-induced diabetic rats.
Autorenporträt
I am Ph.D in clinical biochemistry from Tehran University of Medical Sciences.My research mainly focused on pathobiology of diabetes, the quality control techniques in medical laboratory. Now I am an assistant professor and currently teaches laboratory sciences and postgraduate students of Tabriz University of Medical Sciences.