An important first step in talent development in science, technology, engineering, and mathematics (STEM) is getting individuals excited about STEM through STEM mentoring programs. The essence of STEM mentoring program is to step-up the declining interest in STEM subjects among secondary school students. Therefore, this research investigated the efficacy of STEM mentoring programs on the students' interest towards STEM in some selected secondary schools in South Africa. Specifically, the study analyses the extent to which secondary school students developed interest towards STEM subjects. Following the results from this research, this study then suggests that government should recruit teachers that are vast in STEM mentoring who express interest in developing a supportive, caring relationship and friendship with their mentee(s) in order to enable the students develop career interest in STEM subjects.