Franklyn de Silva, Jane Alcorn

The Elusive Road Towards Effective Cancer Prevention and Treatment

• Gebundenes Buch

Produktbeschreibung

Our understanding of cancer has expanded in multiple directions including pathophysiological, biochemical, toxicological, and pharmacological aspects. Collectively, these areas will strengthen the ability to harness the greater benefit of oncology research to improve patient survival and quality of life and this is illustrated in this volume.

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Produktdetails

• Verlag: Taylor & Francis Ltd (Sales)
• Seitenzahl: 216
• Erscheinungstermin: 28. Oktober 2022
• Englisch
• Abmessung: 234mm x 156mm x 14mm
• Gewicht: 503g
• ISBN-13: 9781032351308
• ISBN-10: 1032351306
• Artikelnr.: 64360921

Autorenporträt

Franklyn De Silva - S. F. De Silva is a Ph.D. candidate in Pharmacy/ Pharmaceutical Sciences (completion 2022) enrolled in the College of Graduate and Postdoctoral Studies, and the College of Pharmacy and Nutrition, at the University of Saskatchewan, Canada. He is a member of the Drug Discovery and Development Research Group. Franklyn has an AS in Biotechnology from Ellsworth College, Iowa, USA; a BS (double major: Biotechnology and Chemistry, minor in Biology) and MS (Biology: Cell Biology and Molecular Pharmacology) from West Texas A & M University, USA; and completed a biomedical research internship at Texas Tech University Health Sciences Center, USA. He has worked in the USA and Canada as a biomedical research scientist in areas involving cell & molecular biology, medicinal chemistry, pharmaco-kinetics/dynamics, xenobiotics, nutrient transporters, cellular metabolism, small molecule drugs, natural products, and nutraceuticals. Jane Alcorn - J. Alcorn is Dean and Professor of the College of Pharmacy and Nutrition, University of Saskatchewan. She has a Doctor of Veterinary Medicine from the Western College of Veterinary Medicine, University of Saskatchewan, and a Ph.D. in Pharmaceutical Sciences (Pharmacokinetics) from the University of Kentucky. Jane Alcorn is a member of the Drug Discovery and Development Research Group and the Cannabinoid Research Initiative of Saskatchewan. Jane's expertise in pharmacokinetics has been applied to numerous collaborative research projects involving cancer and the health benefits of phytochemicals such as flaxseed lignans and the cannabinoids.

Inhaltsangabe

Overview and Current Status of Cancer
Introduction
Incidence, Mortality, and Prevention
Diagnosis and Pathobiology
Introduction
Diagnosis
Evolutionary Paradigms and Origin of Cancer
Heterogeneity and Dynamics of Cancer
Hallmarks of Cancer
Molecular Biology of Carcinogenesis
Genetic Underpinnings
Epigenetic Underpinnings
Characteristics, Events, and Stages in Tumorigenesis
Introduction
Metastases and the Microenvironment
Cell-of-Origin, Disseminated and Circulating Tumor Cells, and Cancer Stem Cells
Tumor-derived Exosomes and Particles
Oncogenic Viruses
Metabolic Syndrome and Cancer Metabolism
Convoluted Neovascularization
Treatments and Challenges
Introduction
Chemotherapy, Radiotherapy, and Targeted Therapy
Immunotherapy
Drug Resistance and Cellular Reprogramming
Efficient Biomarkers
The Role of Nutraceuticals and Natural Products
Physiologically Relevant Nutrikinetics and Nutridynamics
Additional Remarks, Perspectives, and Conclusions
References