The Engines of Life - Perez-Ramirez, Bernardo
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The book is directed to advanced undergraduate and beginning graduate students with general knowledge of chemistry and physics. It can serve as an introduction to the world of protein structure and function with applications to biopharmaceutical development of therapeutic proteins. The book covers the evolution of macromolecules and how building blocks could have assembled into polymeric biological macromolecules, including proteins that are the engines of life. The book emphasizes the general principles and avoids a detailed mathematical treatment of the subjects. In addition, the book…mehr

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Produktbeschreibung
The book is directed to advanced undergraduate and beginning graduate students with general knowledge of chemistry and physics. It can serve as an introduction to the world of protein structure and function with applications to biopharmaceutical development of therapeutic proteins. The book covers the evolution of macromolecules and how building blocks could have assembled into polymeric biological macromolecules, including proteins that are the engines of life. The book emphasizes the general principles and avoids a detailed mathematical treatment of the subjects. In addition, the book emphasizes the scientists involved in the great discoveries, their struggles and controversies in developing protein chemistry, and the evolution of the techniques to advance the knowledge of the subject. The book is divided into nine chapters, starting with the potential origin of life and protein evolution, structure and function, thermodynamic aspects and unique proteins.
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Autorenporträt
Bernardo Perez-Ramirez is the Global Head of CMC-Drug Device Integration at Sanofi Pharmaceuticals. His current responsibilities include scientific and strategic advice on CMC-Drug Device integration. He has over twenty-five years of experience in the biopharmaceutical industry, particularly in the formulation and drug product development for therapeutic proteins (enzyme, monoclonal antibodies, agonists, growth factors, combination products, and gene therapy), including drug-device integration and technology transfer. Before his tenure at Sanofi/Genzyme, he spent eight years at Genetics Institute/Wyeth (now Pfizer) where he was responsible for formulating implantable combination products and implementing device controls for biologic products. He received his PhD in chemistry/biochemistry from the University of Missouri and did postdoctoral research on the physical biochemistry of proteins at Brandeis University. He has been an active participant in different focus scientific groups and co-organizer of conferences, giving lectures at different universities within the US and Europe. He is an Adjunct Professor at the Department of Biomedical Engineering at Tufts University, Boston. Honorary Professor of Formulation & Drug Product Development, School of BioSciences at the University of Nottingham-United Kingdom. Member of the American Society for Biochemistry and Molecular Biology (US); elected fellow of the Royal Society of Chemistry and the Royal Society of Arts (England).