The Epstein-Barr Virus

Herausgegeben von Epstein, M. A.; Achong, B. G.

• Broschiertes Buch

Produktbeschreibung

The Epstein-Barr virus was discovered 15 years ago. Since that time an immense body of information has been accumu lated on this agent which has come to assume great signifi cance in many different fields of biological science. Thus, the virus has very special relevance in human medicine and oncology, in tumor virology, in immunology, and in mole cular virology, since it is the cause of infectious mononu cleosis and also the first human cancer virus, etiologically related to endemic Burkitt's lymphoma and probably to nasopharyngeal carcinoma. In addition, continuous human lymphoid cell lines initiated and maintained by the transform ing function of the virus genome provide a laboratory tool with wide and ever-growing applications. Innumerable papers on the Epstein-Barr virus have ap peared over recent years and reports of work with this agent now constitute a veritable flood. The present book provides the first and only comprehensive, authoritative over-view of all aspects of thevirus by authors who have been the original and major contributors in their particular disciplines. A complete and up-to-date survey of this unique and important agent is thus provided which should be of great interest to experts, teachers, and students engaged in cancer research, virology, immunology, molecular biology, epide miology, and cell culture. Where topics have been dealt with from more than one of these viewpoints, some inevitable overlap and duplication has resulted; although this has been kept to a minimum, it has been retained in some places because of positive usefulness.

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Produktdetails

• Verlag: Springer / Springer Berlin Heidelberg / Springer, Berlin
• Artikelnr. des Verlages: 978-3-642-67238-5
• Softcover reprint of the original 1st ed. 1979
• Seitenzahl: 484
• Erscheinungstermin: 13. Dezember 2011
• Englisch
• Abmessung: 244mm x 170mm x 27mm
• Gewicht: 833g
• ISBN-13: 9783642672385
• ISBN-10: 3642672388
• Artikelnr.: 36118180

Inhaltsangabe

List of Contents.- 1 Introduction: Discovery and General Biology of the Virus.- 2 Morphology of the Virus and of Virus-Induced Cytopathologic Changes.- 3 EB Virus-Induced Antigens.- 4 Seroepidemiology of the Virus.- 5 Biochemistry of the Virus and Its Effects on the Metabolism of Infected Cells.- 6 Molecular Probes and Genome Homology.- 7 Biochemical Detection of the Virus Genome.- 8 The State of the Virus Genome in Transformed Cells and Its Relationship to Host Cell DNA.- 9 Early Events in Transformation of Human Lymphocytes by the Virus.- 10 Transformation by the Virus In Vitro.- 11 The Nature of Lymphoid Cell Lines and Their Relationship to the Virus.- 12 Activation of the Viral Genome In Vitro.- 13 The Virus as the Etiologic Agent of Infectious Mononucleosis.- 14 The Relationship of the Virus to Burkitt's Lymphoma.- 15 The Relationship of the Virus to Nasopharyngeal Carcinoma.- 16 Experimental Carcinogenicity by the Virus in Vivo.- 17 Comparative Aspects: Oncogenic Animal Herpesviruses.- 18 Demographic Studies Implicating the Virus in the Causation of Burkitt's Lymphoma; Prospects for Nasopharyngeal Carcinoma.- 19 Vaccine Control of EB Virus-Associated Tumors.