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The aim of this study was to improve the commercialization rate in Universiti Teknologi Malaysia (UTM), for achieving this goal variety factors and issues were examined to identify how they effect on the procedure of university commercialization. These factors include role of technology transfer office /center, availability of finance, availability of potential licensee and entrepreneurial orientation (EO) among university researcher. Among these four factors, this book focused more on the entrepreneurial orientation (EO) among academic researchers and its effect on the commercialization rate in UTM. This study was based on a qualitative research method and was designed to use a case study approach. For investigating the factors and issues in this study, a total of ten face-to-face interview was conducted. The respondents were chosen from inventors, researchers, academic entrepreneurs, and Technology Transfer Office staff in UTM. The researcher utilized the content-analysis approach to analyze the data obtained from the semi-structured interviews of the respondents.