Miklos Fuzi

The Fluoroquinolone Connection

Dissimilar Fitness Associated with Resistance to Fluoroquinolones Influences Clonal Dynamics of Multiresistant Bacteria

• Broschiertes Buch

Produktbeschreibung

Author falling back on findings published by his group and reviewing data reported by other scientists shows how the extensive use of fluoroquinolones influenced the evolution of various multiresistant pathogens on a global scale. It is demonstrated that most bacteria will suffer enormous fitness costs when developing high-level resistance to fluoroquinolones. However, a few "skillful" groups of pathogens proved capable of evolving favorable mutations conferring high-level resistance to fluoroquinolones with the concomitant preservation of vitality. As these multiresistant "superbugs" have replaced other pathogens in many facilities they also contributed to the deterioration of the general antibiotic resistance status. Though further epidemiological studies are needed the available data strongly suggest that the judicious use of fluoroquinolones could be based on the constant monitoring of the clonal division of local pathogens: if the proportion of "superbugs" is high a reduction in the use of fluoroquinolones should ameliorate the situation, however, when their proportion remains/becomes low the use of fluoroquinolones should be highly beneficial.

Produktdetails

• Verlag: LAP Lambert Academic Publishing
• Seitenzahl: 52
• Erscheinungstermin: 29. März 2017
• Englisch
• Abmessung: 220mm x 150mm x 4mm
• Gewicht: 97g
• ISBN-13: 9783330063693
• ISBN-10: 3330063696
• Artikelnr.: 47904804

Autorenporträt

Miklos Fuzi ist Mediziner und Mikrobiologe und arbeitet als außerordentlicher Professor an der Semmelweis-Universität in Budapest, Ungarn. Er beschäftigt sich seit mehr als zwanzig Jahren mit Fragen der Antibiotikaresistenz und hat zahlreiche Publikationen über die klonale Dynamik und die Antibiotikaresistenz-Determinanten verschiedener multiresistenter Erreger veröffentlicht.