This book presents advances in the field of neuronal mitochondria - functions, relation to therapeutics, and pharmacology. For scientists and researchers in both industry and academia, this book provides detailed discussion, examples, and approaches, to illustrate the potential of mitochondria as therapeutic targets for neuronal diseases. * Helps readers understand the regulation of mitochondrial cellular processes, such as substrate metabolism, energy production, and programmed versus sporadic cell death * Offers insights on the development of strategies for targeted therapeutic approaches…mehr
This book presents advances in the field of neuronal mitochondria - functions, relation to therapeutics, and pharmacology. For scientists and researchers in both industry and academia, this book provides detailed discussion, examples, and approaches, to illustrate the potential of mitochondria as therapeutic targets for neuronal diseases. * Helps readers understand the regulation of mitochondrial cellular processes, such as substrate metabolism, energy production, and programmed versus sporadic cell death * Offers insights on the development of strategies for targeted therapeutic approaches and potential personalized treatments * Includes examples of mitochondrial drugs, development, and mitochondria-targeted approaches for more efficient treatment methods and further developments in the field * Covers the model systems and approaches needed for the development of new drugs for the central nervous system to provide potential modern therapeutics for neurodegenerative disordersHinweis: Dieser Artikel kann nur an eine deutsche Lieferadresse ausgeliefert werden.
Valentin Gribkoff is an Associate Professor Adjunct in the Department of Internal Medicine at Yale University School of Medicine and is a founding member of The Northwoods Group, a biotech consulting and development consortium. He previously co-edited Structure, Function and Modulation of Neuronal Voltage-Gated Ion Channels (Wiley, 2009) and is a co-editor of the Wiley Series on Neuropharmacology. Elizabeth Jonas is an Associate Professor at the Departments of Internal Medicine, Section of Endocrinology, and Neurobiology at Yale University School of Medicine. J. Marie Hardwick is the David Bodian Professor of Molecular Microbiology and Immunology at The Johns Hopkins Bloomberg School of Public Health.
Inhaltsangabe
Section I: Mitochondrial Structure and Ion Channels
Chapter 1: Mitochondrial Permeability Transition: Look from a Different Angle N. Brustovetsky
Chapter 2: The mitochondrial permeability transition pore, the c-subunit of the F1FO ATP synthase, cellular development and synaptic efficiency E.A. Jonas, G.A. Porter, Jr., G. Beutner, N. Mnatsakanyan and K.A. Alavian
Chapter 3: Mitochondrial channels in neurodegeneration P.M. Peixoto, K.W. Kinnally and Evgeny Pavlov
Chapter 4: Mitochondrial Ca¯2+ Transport in the Control of Neuronal Functions: Molecular and Cellular Mechanisms Y.M. Usachev
Section II: Control of Mitochondrial Signaling Networks
Chapter 5: AMP-activated Protein Kinase (AMPK) as a Cellular Energy Sensor and Therapeutic Target for Neuroprotection P. Weisova, S. Pfeiffer and J.H.M. Prehn
Chapter 6: HDAC6: a molecule with multiple functions in neurodegenerative diseases Y. Yan and R. Jiao
Chapter 7: Neuronal Mitochondrial Transport A.L. Knight, Y. Chen, T. Sun and Z.H. Sheng
Chapter 8: Mitochondria in Control of Hypothalamic Metabolic Circuits C.M. Nasrallah and T.L. Horvath
Chapter 9: Mitochondria Anchored at the Synapse G.A. Spirou, D. Jackson and G.A. Perkins
Section III: Defective Mitochondrial Dynamics and Mitophagy
Chapter 10: Neuronal mitochondria are different: relevance to neurodegenerative disease S.B. Berman and J.M. Hardwick
Chapter 11: PINK1 as a Sensor for Mitochondrial Function: Dual Roles E.K. Steer, M.K. Dail and C.T. Chu
Chapter 12: A get-together to tear it apart: the mitochondrion meets the cellular turnover machinery G.L. McLelland and E.A. Fon
Chapter 13: Mitochondrial involvement in neurodegenerative dementia L. Bonanni, V. Frazzini, A. Thomas and M. Onofrj
Section IV: Mitochondria-Targeted Therapeutics and Model Systems
Chapter 14: Neuronal Mitochondria as a Target for the Discovery and Development of New Therapeutics V.K. Gribkoff
Chapter 15: Mitochondria as a Therapeutic Target for Alzheimer's disease C.H.L. Hung, S.S.Y. Chung, S.M.Y. Lee and R.C.C. Chang
Chapter 16: Mitochondria in Parkinson Disease G. Arena and E.M. Valente
Chapter 17: Therapeutic Targeting of Neuronal Mitochondria in Brain Injury H.M. Yonutas, E.D. Hall and P.G. Sullivan
Chapter 18: The use of fibroblasts from patients with inherited mitochondrial disorders for pathomechanistic studies and evaluation of therapies D. Soiferman and A. Saada
Section I: Mitochondrial Structure and Ion Channels
Chapter 1: Mitochondrial Permeability Transition: Look from a Different Angle N. Brustovetsky
Chapter 2: The mitochondrial permeability transition pore, the c-subunit of the F1FO ATP synthase, cellular development and synaptic efficiency E.A. Jonas, G.A. Porter, Jr., G. Beutner, N. Mnatsakanyan and K.A. Alavian
Chapter 3: Mitochondrial channels in neurodegeneration P.M. Peixoto, K.W. Kinnally and Evgeny Pavlov
Chapter 4: Mitochondrial Ca¯2+ Transport in the Control of Neuronal Functions: Molecular and Cellular Mechanisms Y.M. Usachev
Section II: Control of Mitochondrial Signaling Networks
Chapter 5: AMP-activated Protein Kinase (AMPK) as a Cellular Energy Sensor and Therapeutic Target for Neuroprotection P. Weisova, S. Pfeiffer and J.H.M. Prehn
Chapter 6: HDAC6: a molecule with multiple functions in neurodegenerative diseases Y. Yan and R. Jiao
Chapter 7: Neuronal Mitochondrial Transport A.L. Knight, Y. Chen, T. Sun and Z.H. Sheng
Chapter 8: Mitochondria in Control of Hypothalamic Metabolic Circuits C.M. Nasrallah and T.L. Horvath
Chapter 9: Mitochondria Anchored at the Synapse G.A. Spirou, D. Jackson and G.A. Perkins
Section III: Defective Mitochondrial Dynamics and Mitophagy
Chapter 10: Neuronal mitochondria are different: relevance to neurodegenerative disease S.B. Berman and J.M. Hardwick
Chapter 11: PINK1 as a Sensor for Mitochondrial Function: Dual Roles E.K. Steer, M.K. Dail and C.T. Chu
Chapter 12: A get-together to tear it apart: the mitochondrion meets the cellular turnover machinery G.L. McLelland and E.A. Fon
Chapter 13: Mitochondrial involvement in neurodegenerative dementia L. Bonanni, V. Frazzini, A. Thomas and M. Onofrj
Section IV: Mitochondria-Targeted Therapeutics and Model Systems
Chapter 14: Neuronal Mitochondria as a Target for the Discovery and Development of New Therapeutics V.K. Gribkoff
Chapter 15: Mitochondria as a Therapeutic Target for Alzheimer's disease C.H.L. Hung, S.S.Y. Chung, S.M.Y. Lee and R.C.C. Chang
Chapter 16: Mitochondria in Parkinson Disease G. Arena and E.M. Valente
Chapter 17: Therapeutic Targeting of Neuronal Mitochondria in Brain Injury H.M. Yonutas, E.D. Hall and P.G. Sullivan
Chapter 18: The use of fibroblasts from patients with inherited mitochondrial disorders for pathomechanistic studies and evaluation of therapies D. Soiferman and A. Saada
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