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This book is a result of the study that was conducted on the strategies used by universities in preventing HIV infection among undergraduate students using the case study of Mbarara University of Science and Technology (MUST) Uganda. The study specifically establishes the strategies used by MUST to prevent HIV infection among undegraduate students, assesses the effectiveness of the MUST strategies in preventing HIV and explores the challenges faced by MUST in preventing HIV. The findings reveal that MUST uses a number of strategies like bahavioral change strategies like abstinence, being faithful and consistent and correct use of condoms, HIV/AIDS education and awareness, the Peer Project and collaboration with other organizations like AIDS Information Center, TASO, Marie Stopes and Mbarara Blood Bank. The above strategies have their own short comings like the HIV Institutional Policy which is not well disseminated to both students and staff. The university faces a number of challenges in preventing HIV/AIDS like knowledge gaps about HIV/AIDS, students' engagement in risky sexual behaviors, stigma and low levels of utilization of VCT services.