The Human T-Cell Receptor Repertoire and Transplantation

Herausgegeben:Elsen, Peter van den

• Broschiertes Buch

Produktbeschreibung

these analyses it became clear that the MHC class I molecule com prised a distinct groove on the external side of the molecule. The sides of the groove are formed by the a-helical structures of the a and a 1 2 domains and a floor which is formed by 8 anti-parallel 13 strands. The various polymorphic residues, as determined from DNA sequence analysis, are localized within these a-helices and 13-plated sheets within the groove. More importantly, these analyses also revealed the presence of elec tron-dense material in the groove. This material was subsequently iden 568 10 tified as a linear peptide of 8-10 amino acids long. - -- High resolu tion crystallographic analyses of the class I MHC structure have revealed the existence of so-called pockets within the grooves of the MHC class I molecules. These pockets designated A-F, exhibited allele-specificity and are directly involved in the binding of the peptide, primarily through interaction with the dominant anchor residues as found in MHC class I associated pep tides. 6,7,9,11 The class II MHC antigens consist on the cell surface of a 34 kD a chain non-covalently associated with a 28 kD 13 chain. With the excep tion of the DR a-chain, all other MHC class II a and 13 chains are poly morphic.

Produktdetails

• Molecular Biology Intelligence Unit
• Verlag: Springer / Springer Berlin Heidelberg / Springer, Berlin
• Artikelnr. des Verlages: 978-3-662-22496-0
• Softcover reprint of the original 1st ed. 1995
• Seitenzahl: 188
• Erscheinungstermin: 13. November 2013
• Englisch
• Abmessung: 254mm x 178mm x 11mm
• Gewicht: 366g
• ISBN-13: 9783662224960
• ISBN-10: 3662224968
• Artikelnr.: 39916822

Inhaltsangabe

1. General Introduction.- 2. The Circulating Human Peripheral T-Cell Repertoire.- 3. T Cell Receptor Usage in Alloreactivity.- 4. T-Cell Receptor Usage Among Graft Infiltrating T Lymphocytes.- 5. T-Cell Receptor V Gene Usage in T-Cell Lines Propagated from Graft-Infiltrating T Lymphocytes in Needle Biopsies of Rejecting Renal Allografts.- 6. Structure of T Cell Receptor V? and V? Chains Expressed by T-Lymphocytes in Cardiac Allograft Derived Cell Lines.- 7. Involvement of Minor Histocompatability Antigens in the Rejection of an HLA Identical Renal Transplant from a Living Related Donor.- 8. Concluding Remarks.