The present work initially provides a review of the scientific literature regarding the COVID-19 Pandemic and society's responses. No effort is spared to exhaust the scientific literature involving databases such as ScienceDirect and PubMed in the construction of this work. Infective endocarditis (IE) is contained in the state of the art of this book, and is also treated from a dental perspective. The book brings summaries of several research studies involving the impact of the COVID-19 pandemic on health in different contexts. This book presents a proposal that pushes the boundaries of science through an ecological study involving the impacts of the COVID-19 pandemic on deaths from infective endocarditis (IE) in Brazil.