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HIV/AIDS (Human Immune Virus/ Acquired Immune Deficiency Syndrome) affects human including pregnant women and the unborn. As a step to mitigate the effect of HIV/AIDS on Pregnant women and Unborn Child in Enugu State, proper health education has been advised. This research work looked into (i) Concept of HIV/AIDS, (ii) Mode of Transmission, (iii) Impact of HIV on Pregnancy (IV) Factors Responsible for the prevalence of HIV among Women and (V) Prenatal Transmission. This work serves as a reference for academics, researchers and Health workers.