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Cadmium is an extremely toxic industrial and environmental pollutant. Cadmium acts as a catalyst in forming reactive oxygen species. More attentions have been paid to the natural antioxidants owing to its defensive effects against heavy metals-caused toxicities, particularly whenever oxidative stress are involved. This work aimed to assess the possible protecting effects of Nigella sativa oil and Virgin olive oil on rat administrated cadmium chloride. The results indicate that Nigella sativa oil and Virgin olive oil can be used as potentially effective therapeutic agents for workers in factories that their products are contaminated with Cd particularly cement factories. The book is perfect for biomedical science researchers.