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The aim of the research was to examine the influence of intrinsic and extrinsic motivational strategies on job performance of NHS nurses in London. This study was conducted in the Royal Free NHS Foundation Trust Hospital in London, UK. A qualitative phenomenology approach was used to conduct this study; homogenous purposive sampling technique was employed to select eight nurses (5 junior nurses and 3 senior nurses=8). Individual semi-structured interviews were conducted for data collection and thematic approach was utilized for data analysis. Seven main themes were identified from this study to address the research questions. It was concluded in this study that intrinsic and extrinsic motivation are essential strategies necessary to significantly influence job performance of nurses in the RFH to render high quality patient care. A recommendation was made to the UK government and NHS to set out strategies to incorporate intrinsic and extrinsic motivational techniques to keep nurses motivated and prevent increased turnover rates, intention to leave the profession and compromised patient care.