This paper aims to show the intense doctrinal and jurisprudential development of the proposed topic, starting from the essential premise that the current constitutional configuration of the Constitutional Block constitutes a vindication of the jurisprudential lines established during the "belle époque" of the Bolivian Constitutional Court (1999-2006); This is in order to then examine the current resizing of the block in the Constitutional State of Law, in the light of pluralism and interculturality as new paradigms in constitutional interpretation, through the insertion of plural values and supreme guiding principles of the constitutional order in force in the country, making special reference to the main pronouncements of the Inter-American Court of Human Rights in the exercise of conventionality control, in view of its scarce knowledge by justice operators and public authorities, thus justifying the need and relevance of its application in the resolution of concrete cases.