This book discuss about the prevalence of Post-Dural puncture headache/PDPH and associated factor after spinal anesthesia in patient undergoing orthopedic and urological procedure in Black Lion referral Hospital Addis Ababa, Ethiopia. Different Factor was tested for association with post-dural puncture headache but only number of spinal attempt and gauge of the spinal needle was was found significantly associated with post-dural puncture headache. Recommendation was forwarded to different stake holders to decrease the prevalence of PDPH in the hospital.