The Major Approaches for Boosting Aqueous Solubility, Dissolution Rate, and Oral Bioavailability Development of Solid Dispersion of Insoluble Pharmaceuticals Based on Hydrophilic Carriers and Hydrotropic Blends. DE
-
- Englisch ausgewählt
65,99 €
UVP
79,90 €
inkl. gesetzl. MwSt.,
Beschreibung
Produktdetails
Einband
Taschenbuch
Erscheinungsdatum
13.02.2023
Verlag
LAP LAMBERT Academic PublishingSeitenzahl
168
Maße (L/B/H)
22/15/1,1 cm
Gewicht
268 g
Sprache
Englisch
ISBN
978-620-5-64085-2
Poorly water-soluble drugs have emerged as the central challenging aspect that should be probed by scientists during drug development. These obstacles change the way of development of medicines from formulation to overcoming such types of problems. Several methods have been used to treat these limitations. Still, the solid dispersion method is getting the most substantial attention because it can improve the solubility, dissolution rate, and bioavailability of such kinds of drugs effectively. That's why it was recognized as the most effective method for that purpose during drug development. Antihyperlipidemic agent atorvastatin calcium (ATV) faced a problem after oral administration due to low water solubility characteristics. Boosting the solubility and oral bioavailability of such kinds of drugs are the major obstacles that formulation scientists faced. This Study's aim was to enhance the solubility and dissolution rate of ATV by the formation of solid dispersion-based hydrotropic blends. Solid dispersion-based hydrotropic blends can result in the production of the dosage forms of practically insoluble drugs with an optimum enhancement ratio in their solubility.
Noch keine Bewertungen vorhanden
Verfassen Sie die erste Bewertung zu diesem Artikel
Helfen Sie anderen Kundinnen und Kunden durch Ihre Meinung.
Kurze Frage zu unserer Seite
Vielen Dank für dein Feedback
Wir nutzen dein Feedback, um unsere Produktseiten zu verbessern. Bitte habe Verständnis, dass wir dir keine Rückmeldung geben können. Falls du Kontakt mit uns aufnehmen möchtest, kannst du dich aber gerne an unseren Kund*innenservice wenden.
zum Kundenservice