The Mathematics of Oxygen and Substrate Diffusion
Mathematical Analysis of Oxygen, Myoglobin-Facilitated Oxygen and Substrate Diffusion within an Interacting Multi-capillary System in Skeletal Muscle
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A theoretical model for oxygen and substratetransport to tissues within skeletal muscle involvingseveral interacting capillaries has been developed.It involves an elegant technique that discretizes thetransport problem in a tissue with large number ofcapillaries. The technique can be equally applied toother heat transport problems with actual anatomicalinformation.For oxygen, the role of myoglobin and the effect ofaxial diffusion have been considered. For themyoglobin model, myoglobin facilitates oxygendiffusion into tissue and can prevent hypoxia due tothe interaction of the capillaries. The ...
A theoretical model for oxygen and substrate
transport to tissues within skeletal muscle involving
several interacting capillaries has been developed.
It involves an elegant technique that discretizes the
transport problem in a tissue with large number of
capillaries. The technique can be equally applied to
other heat transport problems with actual anatomical
information.
For oxygen, the role of myoglobin and the effect of
axial diffusion have been considered. For the
myoglobin model, myoglobin facilitates oxygen
diffusion into tissue and can prevent hypoxia due to
the interaction of the capillaries. The analysis
yields a great deal of information about hypoxia,
since as shown, a multicapillary model of the type
presented here is needed to determine if the tissue
is truly hypoxic.
Because capillary length is large compared to
capillary spacing, axial diffusion is a small
perturbation to the solution without axial diffusion.
The effect of axial diffusion is found using
perturbation methods.
For the substrate model, there can be large
differences between the substrate concentration
in the capillary and that in the tissue, depending on
the permeability of the capillary endothelium.
transport to tissues within skeletal muscle involving
several interacting capillaries has been developed.
It involves an elegant technique that discretizes the
transport problem in a tissue with large number of
capillaries. The technique can be equally applied to
other heat transport problems with actual anatomical
information.
For oxygen, the role of myoglobin and the effect of
axial diffusion have been considered. For the
myoglobin model, myoglobin facilitates oxygen
diffusion into tissue and can prevent hypoxia due to
the interaction of the capillaries. The analysis
yields a great deal of information about hypoxia,
since as shown, a multicapillary model of the type
presented here is needed to determine if the tissue
is truly hypoxic.
Because capillary length is large compared to
capillary spacing, axial diffusion is a small
perturbation to the solution without axial diffusion.
The effect of axial diffusion is found using
perturbation methods.
For the substrate model, there can be large
differences between the substrate concentration
in the capillary and that in the tissue, depending on
the permeability of the capillary endothelium.
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