New Treatment Strategy of Hepatitis C virus by using natural supplement probiotics side by side the treatment of HCV which act as antiviral and antibacterial Factor and also as immune enhancer. Probiotics increase the treatment response rate to HCV treatments in shorter time. Probiotics reduce the enzyme of lipid biosynthesis DGAT1 which act as a key factor in Hepatitis C virus production. Reduction of DGAT1 enzyme plays an important role in reduction of Hepatitis C viral load.