The Melanocortin Receptors

Herausgegeben:Cone, Roger D.

• Broschiertes Buch

Produktbeschreibung

Roger Cone and a distinguished team of expert investigators provide the first major treatment of this critically important receptor family. The book illuminates the structure and function of these receptors through a wide-ranging review of the latest findings concerning the biology, physiology, and pharmacology of their peptide ligands and covers the major melanocortin peptides, Melanocortin-1-Receptors through Melanocortin-5-Receptors. Topics include the characterization of the melanocortin receptors, the biochemical mechanism of receptor action, and receptor function and regulation. Timely and authoritative, The Melanocortin Receptors offers an up-to-date knowledge base on the remarkably complex structure and functions of the melanocortins, a guide that will prove invaluable for today's neuroscientists, endocrinologists, pharmacologists, and other clinical and experimental investigators working in this fast moving field.

Produktdetails

• The Receptors
• Verlag: Humana / Humana Press / Springer, Berlin
• Artikelnr. des Verlages: 978-1-61737-082-3
• Softcover reprint of the original 1st ed. 2000
• Seitenzahl: 564
• Erscheinungstermin: 8. Dezember 2010
• Englisch
• Abmessung: 229mm x 152mm x 31mm
• Gewicht: 807g
• ISBN-13: 9781617370823
• ISBN-10: 1617370827
• Artikelnr.: 32201824

Inhaltsangabe

I. Historical Perspectives.- 1 - Proopiomelanocortin and the Melanocortin Peptides.- 2 - Melanocortins and Pigmentation.- 3 - Melanocortins and Adrenocortical Function.- 4 - Effects of Melanocortins in the Nervous System.- 5 - Peripheral Effects of Melanocortins.- II. Characterization of the Melanocortin Receptors.- 6 - Melanocortin Receptor Expression and Function in the Nervous System.- 7 - Cloning of the Melanocortin Receptors.- III. Biochemical Mechanism of Receptor Action.- 8 - The Molecular Pharmacology of Alpha-Melanocyte Stimulating Hormone: Structure Activity Relationships for Melanotropins at Melanocortin Receptors.- 9 - In Vitro Mutagenesis Studies of Melanocortin Receptor Coupling and Ligand Binding.- IV. Receptor Function.- 10 - The Melanocortin-1 Receptor.- 11 - The Human Melanocortin-1 Receptor.- 12 - The Melanocortin-2 Receptor in Normal Adrenocortical Function and Familial Adrenocorticotropic Hormone Resistance.- 13 - The Melanocortin-3 Receptor.- 14 - The Melanocortin-4 Receptor.- 15 - The Melanocortin-5 Receptor.- V. Receptor Regulation.- 16 - Regulation of the Melanocortin Receptors by Agouti.- 17 - Melanocortins and Melanoma.- 18 - Regulation of the Mouse and Human Melanocortin-1 Receptor.- VI. Future Vistas.- 19 - Future Vistas.

Rezensionen

"New data on melanocortin receptors 1-5 and their regulation are the topic of several chapters. A complete, well referenced text of interest to all endocrinologists, neuroscientists, geneticists, physiologists and pharmacologists." - Journal of Pediatric Endocrinology & Metabolism