I organized this symposium, "Molecular Immunology of Complex Carbohydrates-2 (MICC-2)," at the Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan th between August 28-September 2, 1999, as a satellite meeting of the 15 International Glycoconjugate Conference (held August 22-27 in Tokyo, Japan). I also held a Taiwan Canada Glycobiology Workshop after this meeting at the Institutes of Biological Chemistry and Chemistry. To promote glycobiology in Taiwan, I offered a Complexs Carbohydrate & Medicine-2 workshop at the Glyco- Research Laboratory, College of Medicine, Chang Gung…mehr
I organized this symposium, "Molecular Immunology of Complex Carbohydrates-2 (MICC-2)," at the Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan th between August 28-September 2, 1999, as a satellite meeting of the 15 International Glycoconjugate Conference (held August 22-27 in Tokyo, Japan). I also held a Taiwan Canada Glycobiology Workshop after this meeting at the Institutes of Biological Chemistry and Chemistry. To promote glycobiology in Taiwan, I offered a Complexs Carbohydrate & Medicine-2 workshop at the Glyco- Research Laboratory, College of Medicine, Chang Gung University, Kwei-san, Tao-yuan, Taiwan before the MICC-2 symposium. The lecture and poster materials of these three meetings are collected in these proceedings, which are divided into five Sections and two Appendixes. Section I, entitled "Protein-Carbohydrate Interactions of Plant and Animal Lectins," provides current concepts of lectin-carbohydrate interactions; classification of lectins, basedon amino acid sequences, molecular structures, and lectin affinity for carbohydrates. However, the relationships between amino acid sequences and carbohydrate affinity of lectins have to be more thoroughly characterized. The reviews on animal lectins in this Section explore new areas of lectins. Section II, "Aspects of Structure and Antigenicity of Glycoconjugates," provides important information on structural concepts of glyco immunology. "Glycotope Expression (Glycosylation), Metabolism and Functions," which play important roles in life processes, are discussed in Section III. Four articles on advances in knowledge on structural roles of glycans and treatment of cancer are discussed in Section IV.
SECTION I Carbohydrate-Protein Interactions: Plant and Animal Lectins.- I-1 The Structural Basis for Carbohydrate Recognition by Lectins.- I-2 Lectin Cross-linking Interactions with Multivalent Carbohydrates.- I-3 Classification of Plant Lectins in Families of Structurally and Evolutionary Related Proteins.- I-4 Expression of Binding Properties of Gal/Ga1NAc Reactive Lectins by Mammalian Glycotopes.- I-5 'Glyco-Epitope' Assignments for the Selectins: Advances Enabled by the Neoglycolipid Technology in Conjunction with Synthetic Carbohydrate Chemistry.- I-6 Animal Lectins: From Initial Description to Elaborated Structural and Functional Classification.- I-7 Galectins and Other Endogenous Carbohydrate-Binding Proteins of Animal Bladder.- I-8 Binding Properties and Applications of Aplysia Gonad Lectin.- I-9 Lectin and Anti-carbohydrate Antibody Assays Using Chemically Modified Ligands.- SECTION II Structure and Antigenicity of Glycoconjugates.- II-1 Intramolecular Carbohydrate-Protein Interaction.- II-2 Red Blood Cell Antigens Responsible for Inherited Types of Polyagglutination.- II-3 Antigenic Properties of Human Glycophorins-An Update.- II-4 KDN-Containing Glycoprotein from Loach Skin Mucus.- II-5 Glycoconjugates from Parasitic Helminths: Structure Diversity and Immunobiological Implications.- II-6 Glycosyl Phosphatidylinositol-Linked Glycoconjugates: Structure, Biosynthesis, and Function.- II-7 Enzymatic and Chemical Approaches for the Synthesis of Sialyl Glycoconjugates.- SECTION III Glycotopes Expression, Metabolism, and Functions.- III-1 The Genetic Regulation of Fucosylated and Sialylated Antigens on Developing Myeloid Cells.- III-2 Transcriptional Regulation of Expression of Carbohydrate Ligands for Cell Adhesion Molecules in the Selectin Family.- III-3Biosynthesis and Function of ?1,6 Branched Mucin-Type Glycans.- III-4 Differentiation-Associated Expression of ß-N-acetylgalactosaminylated N-linked Oligosaccharides in Mammary Epithelial Cells.- III-5 Metabolism and Role of O-Acetylated Sialic Acids.- III-6 Contradictory Functions of the Sulfatide in the Blood Coagulation System.- III-7 Interaction of GM2 Activator Protein with Glycosphingolipids.- SECTION IV Complex Carbohydrates in Development and Treatment of Cancer.- IV-1 Tumor-Associated Carbohydrate Antigens Defining Tumor Malignancy: Basis for Development of Anti-cancer Vaccines.- IV-2 Carbohydrate-Mediated Adhesion of Human Colon Carcinoma Cells to Human Liver Sections.- IV-3 O-Linked N-Acetylglucosamine and Cancer: Messages from the Glycosylation of c-Myc.- IV-4 Analysis of a Murine Anti-Ganglioside GD2 Monoclonal Antibody Expressing Both IgG2a and IgG3 Isotypes: Monoclonality, Apoptosis Triggering, and Activation of Cellular Cytotoxicity on Human Melanoma Cells.- SECTION V Complex Carbohydrates in Microbial and Viral Infections and Vaccine Design.- V-1 Pathogen-Host Protein-Carbohydrate Interactions as the Basis of Important Infections.- V-2 Host Mediated Variation and Receptor Binding Specificity of Influenza Viruses.- V-3 Bacterial Polysaccharides as Vaccines - Immunity and Chemical Characterization.- V-4 The Conformational Epitope of Type III Group B Streptococcus Capsular Polysaccharide.- V-5 T-independent IgA Responses to Microbial Polysaccharides.- V-6 Protective Immunity and Gene Expression Related to Pneumococcal Glycoconjugates.- V-7 Structure and Functional Genomics of Lipopolysaccharide Expression in Haemophilus influenzae.- V-8 Molecular Mimicry of Host Structures by Lipooligosaccharides of Neisseria meningitidis: Characterization ofSialylated and Nonsialylated Lacto-N-Neotetraose (Gal?1-4G1cNAc?1-3Gal?1-4Glc) Structures in Lipooligosaccharides using Monoclonal Antibodies and Specific Lectins.- V-9 NMR and Molecular Modeling of Complex Carbohydrates and Carbohydrate-Protein Interactions: Applications to Anti-bacteria Vaccines.- Append.- A-I A Guide to the Carbohydrate Specificities of Applied Lectins-2 (Updated in 2000).- A-II A Guide to Monoclonal Antibodies Directed to Glycotopes.
SECTION I Carbohydrate-Protein Interactions: Plant and Animal Lectins.- I-1 The Structural Basis for Carbohydrate Recognition by Lectins.- I-2 Lectin Cross-linking Interactions with Multivalent Carbohydrates.- I-3 Classification of Plant Lectins in Families of Structurally and Evolutionary Related Proteins.- I-4 Expression of Binding Properties of Gal/Ga1NAc Reactive Lectins by Mammalian Glycotopes.- I-5 'Glyco-Epitope' Assignments for the Selectins: Advances Enabled by the Neoglycolipid Technology in Conjunction with Synthetic Carbohydrate Chemistry.- I-6 Animal Lectins: From Initial Description to Elaborated Structural and Functional Classification.- I-7 Galectins and Other Endogenous Carbohydrate-Binding Proteins of Animal Bladder.- I-8 Binding Properties and Applications of Aplysia Gonad Lectin.- I-9 Lectin and Anti-carbohydrate Antibody Assays Using Chemically Modified Ligands.- SECTION II Structure and Antigenicity of Glycoconjugates.- II-1 Intramolecular Carbohydrate-Protein Interaction.- II-2 Red Blood Cell Antigens Responsible for Inherited Types of Polyagglutination.- II-3 Antigenic Properties of Human Glycophorins-An Update.- II-4 KDN-Containing Glycoprotein from Loach Skin Mucus.- II-5 Glycoconjugates from Parasitic Helminths: Structure Diversity and Immunobiological Implications.- II-6 Glycosyl Phosphatidylinositol-Linked Glycoconjugates: Structure, Biosynthesis, and Function.- II-7 Enzymatic and Chemical Approaches for the Synthesis of Sialyl Glycoconjugates.- SECTION III Glycotopes Expression, Metabolism, and Functions.- III-1 The Genetic Regulation of Fucosylated and Sialylated Antigens on Developing Myeloid Cells.- III-2 Transcriptional Regulation of Expression of Carbohydrate Ligands for Cell Adhesion Molecules in the Selectin Family.- III-3Biosynthesis and Function of ?1,6 Branched Mucin-Type Glycans.- III-4 Differentiation-Associated Expression of ß-N-acetylgalactosaminylated N-linked Oligosaccharides in Mammary Epithelial Cells.- III-5 Metabolism and Role of O-Acetylated Sialic Acids.- III-6 Contradictory Functions of the Sulfatide in the Blood Coagulation System.- III-7 Interaction of GM2 Activator Protein with Glycosphingolipids.- SECTION IV Complex Carbohydrates in Development and Treatment of Cancer.- IV-1 Tumor-Associated Carbohydrate Antigens Defining Tumor Malignancy: Basis for Development of Anti-cancer Vaccines.- IV-2 Carbohydrate-Mediated Adhesion of Human Colon Carcinoma Cells to Human Liver Sections.- IV-3 O-Linked N-Acetylglucosamine and Cancer: Messages from the Glycosylation of c-Myc.- IV-4 Analysis of a Murine Anti-Ganglioside GD2 Monoclonal Antibody Expressing Both IgG2a and IgG3 Isotypes: Monoclonality, Apoptosis Triggering, and Activation of Cellular Cytotoxicity on Human Melanoma Cells.- SECTION V Complex Carbohydrates in Microbial and Viral Infections and Vaccine Design.- V-1 Pathogen-Host Protein-Carbohydrate Interactions as the Basis of Important Infections.- V-2 Host Mediated Variation and Receptor Binding Specificity of Influenza Viruses.- V-3 Bacterial Polysaccharides as Vaccines - Immunity and Chemical Characterization.- V-4 The Conformational Epitope of Type III Group B Streptococcus Capsular Polysaccharide.- V-5 T-independent IgA Responses to Microbial Polysaccharides.- V-6 Protective Immunity and Gene Expression Related to Pneumococcal Glycoconjugates.- V-7 Structure and Functional Genomics of Lipopolysaccharide Expression in Haemophilus influenzae.- V-8 Molecular Mimicry of Host Structures by Lipooligosaccharides of Neisseria meningitidis: Characterization ofSialylated and Nonsialylated Lacto-N-Neotetraose (Gal?1-4G1cNAc?1-3Gal?1-4Glc) Structures in Lipooligosaccharides using Monoclonal Antibodies and Specific Lectins.- V-9 NMR and Molecular Modeling of Complex Carbohydrates and Carbohydrate-Protein Interactions: Applications to Anti-bacteria Vaccines.- Append.- A-I A Guide to the Carbohydrate Specificities of Applied Lectins-2 (Updated in 2000).- A-II A Guide to Monoclonal Antibodies Directed to Glycotopes.
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