Each patient has a combination of the genes bound to cardiovascular illnesses. Today there are 3000 illnesses to which individual genetic tests are available. However to interpret such results, for example for polygenic diseases as an essential hypertension without computer systems is extremely difficult. Usually it is bound to a larger flow of information and shortage of clinical geneticists. Besides cognitive abilities of the cardiologist are limited by lack of knowledge in the field of bioinformatics and biotechnology. In this regard the advanced clinical CDS systems are ready to fill these gaps through computer imitation of therapeutic decisions. In this book, we present the short review of CDS technologies of the next generation for the first time. We put in the forefront some of the problems bound to the biomedical analysis of data and we consider strategy in bioinformatics and computer facilities for various detection of SNP.