The Oxford Handbook of Neuronal Protein Synthesis reviews the mechanisms of translational control used by the nervous system, as well as how nervous system functions, such as plasticity and homeostasis, depend on accurate translational control. The handbook extensively covers how dysregulation of protein synthesis can manifest itself in many distinct pathological processes, including neurodevelopmental, neuropsychiatric, and neurodegenerative diseases.
The Oxford Handbook of Neuronal Protein Synthesis reviews the mechanisms of translational control used by the nervous system, as well as how nervous system functions, such as plasticity and homeostasis, depend on accurate translational control. The handbook extensively covers how dysregulation of protein synthesis can manifest itself in many distinct pathological processes, including neurodevelopmental, neuropsychiatric, and neurodegenerative diseases.
Dr. Sossin received undergraduate degrees in Biology and Computer Science from MIT in 1984 and completed his PhD at Stanford in Biological Sciences with Dr. Richard Scheller in 1989. He did post-doctoral work with Dr. Schwartz at Columbia Univeristy in the Center for Neurobiology and Behavior before being appointed Assistant Professor at the Montreal Neurological Institute at McGill University in 1993 where he is now a James McGill Professor. He has been an EJLB Scholar, CIHR investigator and FRSQ Checheur Nationaux. Dr. Sossin has published over 125 papers on the molecular and cellular processes underlying memory formation and maintenance with a particular interest in the role of persistent protein kinases and the regulation of local translation in this process.
Inhaltsangabe
* Part I: Role of Translation Factors * 1. Regulation of Protein Synthesis by eIF4E in the Brain * Kleanthi Chalkiadaki, Stella Kouloulia, Clive R. Bramham, and Christos G. Gkogkas * 2. Translational Control Through the eIF4E Binding Proteins in the Brain * Argel Aguilar-Valles, Edna Matta-Camacho, and Nahum Sonenberg * 3. The Integrated Stress Response in Memory and Cognitive Disorders * Jacqunae L. Mays and Mauro Costa-Mattioli * 4. The Role of the Eukaryotic Elongation Factor 2 (eEF2) Pathway in Neuronal Function * Elham Taha and Kobi Rosenblum * 5. Sidekick No More: Neural Translation Control by p70 ribosomal S6 kinase 1 * Aditi Bhattacharya * Part II: Role of Specific Elements in the mRNA * 6. Dendritic Targeting and Regulatory RNA Control of Local Neuronal Translation * Taesun Eom, Ilham A. Muslimov, Anna Iacoangeli, and Henri Tiedge * 7. Internal Ribosome Entry Site-Mediated Translation in Neuronal Protein Synthesis * Martin Holcik * 8. RNA Modifications in the Central Nervous System * Dan Ohtan Wang * 9. Role of CPEB-Family Proteins in Memory * Kausik Si * 10. FMRP and MicroRNAs in Neuronal Protein Synthesis * Monica C. Lannom and Stephanie Ceman * 11. Focusing on mRNA Granules and Stalled Polysomes Amidst Diverse Mechanisms Underlying mRNA Transport, mRNA Storage and Local Translation * Mina N. Anadolu and Wayne S. Sossin * Part III: Physiological Roles of Translation * 12. Protein Synthesis and Synapse Specificity in Functional Plasticity * Radha Raghuraman, Amrita Benoy, and Sreedharan Sajikumar * 13. Regulation of Synaptic Homeostasis by Translational Mechanisms * Megumi Mori, Jay Penney, and Pejmun Haghighi * 14. Multiple Roles of RNA Regulatory Factors in Neuronal Development and Function in C. elegans * Matthew G. Andrusiak and Yishi Jin * 15. Regulation of mRNA Translation in Axons * Priyanka Patel, Pabitra K. Sahoo, Amar N. Kar, and Jeffery L. Twiss * 16. Protein Synthesis and Translational Control in Neural Stem Cell Development and Neurogenesis * Lamees Mohammad, Joscelyn Wiseman, Sarah Erickson, and Guang Yang * Part IV: Neuronal Protein Synthesis and Disease * 17. Translational Controls in Pain * Sarah Loerch, June Bryan De La Peña, Jane Song, Joseph J. Pancrazio, Theodore J. Price, and Zachary T. Campbell * 18. Dysregulated Translation in Autism Spectrum Disorder * Emanuela Santini and Anders Borgkvist * 19. Neuronal mRNA Translation in Addiction * Emma Puighermanal and Emmanuel Valjent * 20. Dysregulated Protein Synthesis in Major Depression Disorder * Chelcie F. Heaney and Kimberly F. Raab-Graham * 21. Dysregulation of Neuronal Protein Synthesis in Alzheimer's Disease * Tao Ma * 22. RNA-Binding Proteins and Translation in Neurodegenerative Disease * Kent E. Duncan * 23. Role of Eukaryotic Initiation Factor eIF2B in Vanishing White Matter Disease * Truus E. M. Abbink, Lisanne E. Wisse, Xuemin Wang, and Christopher G. Proud * Index
* Part I: Role of Translation Factors * 1. Regulation of Protein Synthesis by eIF4E in the Brain * Kleanthi Chalkiadaki, Stella Kouloulia, Clive R. Bramham, and Christos G. Gkogkas * 2. Translational Control Through the eIF4E Binding Proteins in the Brain * Argel Aguilar-Valles, Edna Matta-Camacho, and Nahum Sonenberg * 3. The Integrated Stress Response in Memory and Cognitive Disorders * Jacqunae L. Mays and Mauro Costa-Mattioli * 4. The Role of the Eukaryotic Elongation Factor 2 (eEF2) Pathway in Neuronal Function * Elham Taha and Kobi Rosenblum * 5. Sidekick No More: Neural Translation Control by p70 ribosomal S6 kinase 1 * Aditi Bhattacharya * Part II: Role of Specific Elements in the mRNA * 6. Dendritic Targeting and Regulatory RNA Control of Local Neuronal Translation * Taesun Eom, Ilham A. Muslimov, Anna Iacoangeli, and Henri Tiedge * 7. Internal Ribosome Entry Site-Mediated Translation in Neuronal Protein Synthesis * Martin Holcik * 8. RNA Modifications in the Central Nervous System * Dan Ohtan Wang * 9. Role of CPEB-Family Proteins in Memory * Kausik Si * 10. FMRP and MicroRNAs in Neuronal Protein Synthesis * Monica C. Lannom and Stephanie Ceman * 11. Focusing on mRNA Granules and Stalled Polysomes Amidst Diverse Mechanisms Underlying mRNA Transport, mRNA Storage and Local Translation * Mina N. Anadolu and Wayne S. Sossin * Part III: Physiological Roles of Translation * 12. Protein Synthesis and Synapse Specificity in Functional Plasticity * Radha Raghuraman, Amrita Benoy, and Sreedharan Sajikumar * 13. Regulation of Synaptic Homeostasis by Translational Mechanisms * Megumi Mori, Jay Penney, and Pejmun Haghighi * 14. Multiple Roles of RNA Regulatory Factors in Neuronal Development and Function in C. elegans * Matthew G. Andrusiak and Yishi Jin * 15. Regulation of mRNA Translation in Axons * Priyanka Patel, Pabitra K. Sahoo, Amar N. Kar, and Jeffery L. Twiss * 16. Protein Synthesis and Translational Control in Neural Stem Cell Development and Neurogenesis * Lamees Mohammad, Joscelyn Wiseman, Sarah Erickson, and Guang Yang * Part IV: Neuronal Protein Synthesis and Disease * 17. Translational Controls in Pain * Sarah Loerch, June Bryan De La Peña, Jane Song, Joseph J. Pancrazio, Theodore J. Price, and Zachary T. Campbell * 18. Dysregulated Translation in Autism Spectrum Disorder * Emanuela Santini and Anders Borgkvist * 19. Neuronal mRNA Translation in Addiction * Emma Puighermanal and Emmanuel Valjent * 20. Dysregulated Protein Synthesis in Major Depression Disorder * Chelcie F. Heaney and Kimberly F. Raab-Graham * 21. Dysregulation of Neuronal Protein Synthesis in Alzheimer's Disease * Tao Ma * 22. RNA-Binding Proteins and Translation in Neurodegenerative Disease * Kent E. Duncan * 23. Role of Eukaryotic Initiation Factor eIF2B in Vanishing White Matter Disease * Truus E. M. Abbink, Lisanne E. Wisse, Xuemin Wang, and Christopher G. Proud * Index
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