Since carrageenan is mainly a food preservative, majority of studies evaluating the effect of carrageenan pays more attention on the intestinal cells (Reports of the Scientific Committee for Food, Thirty-fifth series,1996) and hardly on the oral cavity cells (Gheetha , 2012). Therefore, it is important to give focus on the effect of carrageenan on our oral cavity. This is due to the fact that, oral cavity is the start of the gastrointestinal tract and is formed by an array of cells and tissues that play vital function.