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This study investigates the current clinical understanding of attention-deficit/hyperactivity disorder (ADHD) in children and adolescents of Spanish ethnicity and how both psychopharmacological and neurological elements are part of the multidisciplinary efforts to diagnose and treat this neurodevelopmental disorder. The current discrepancy among clinical professionals regarding the use of psychostimulants to treat these populations is shaping the diagnosis and treatment of this disorder worldwide. Clinical misdiagnosis and pharmacological overdoses are evaluated from selective collected data analyses from academic and professional communities from the last 10 years of scientific research. This study critically examines and reviews the existing practice-based and empirically based literature on ADHD from the clinical psychology perspective to determine (a) what is known currently in the diagnosis and treatment of ADHD in children and adolescents, (b) whether the current clinical knowledge of ADHD is considering the latest neurological and psychopharmacological advancements, and (c) whether ADHD clinical interventions are effective, safe, and improving the well-being of clients.