Three years ago, most authors contributing to this book gathered at the Heinrich Fabri Institute of the University of Tübingen at Blaubeuren near Ulm in Germany for the third conference on "Pineal Gland and Cancer". In 1987, the late Derek Gupta organized the second meeting and published the first book on the topic, 10 years after Vera Lapin, as part of the 25th anniversary celebrations of the Vienna Cancer Research Institute, had held the first meeting. It was in Vienna during the 1930s and 1940s that W. Bergmann and P. Engel demonstrated that pineal extracts possess growth inhibitory…mehr
Three years ago, most authors contributing to this book gathered at the Heinrich Fabri Institute of the University of Tübingen at Blaubeuren near Ulm in Germany for the third conference on "Pineal Gland and Cancer". In 1987, the late Derek Gupta organized the second meeting and published the first book on the topic, 10 years after Vera Lapin, as part of the 25th anniversary celebrations of the Vienna Cancer Research Institute, had held the first meeting. It was in Vienna during the 1930s and 1940s that W. Bergmann and P. Engel demonstrated that pineal extracts possess growth inhibitory properties on experimental rodent tumors and R. Hofstätter reported favorable results when these extracts were given to cancer patients. In the 1970s, Vera Lapin and others reported that surgical removal of the pineal gland (pinealectomy) stimulates experimental tumor growth rendering fundamental support for an involvement of the pineal gland in malignancy. A focal question of past and present research in this field is whether the pineal gland exerts its tumor inhibitory activity primarily or exclusively via melatonin. Currently, it appears that the action of melatonin on experimental tumor growth criti cally depends on the circadian timing of its administration as weH as on the type and stage of cancer, and that primarily highly differentiated tumor ceHs are controHed. Initial clinical applications of the pineal hormone for incurable cancers raise hopes for a promising future use, particularly when combined with other therapies (e. g.Hinweis: Dieser Artikel kann nur an eine deutsche Lieferadresse ausgeliefert werden.
Section I: Significance of the Pineal Gland and Its Hormone Melatonin.- 1 Some Historical Remarks Concerning Research on the Pineal Gland and Cancer.- 2 Biology of the Pineal Gland and Melatonin in Humans.- 3 The Role of Melatonin in the Neuroendocrine System: Multiplicity of Sites and Mechanisms of Action.- 4 The Pineal Gland and Chronobiologic History: Mind and Spirit as Feedsidewards in Time Structures for Prehabilitation.- 5 Melatonin Involvement in Cancer: Methodological Considerations.- Section II: Effect of Tumor Growth on the Production and Secretion of Pineal Melatonin.- 6 Analysis of Melatonin in Patients with Cancer of the Reproductive System.- 7 Melatonin in Patients with Cancer of Extra-Reproductive Location.- 8 The Modulation of Melatonin in Tumor-Bearing Animals: Underlying Mechanisms and Possible Significance for Prognosis.- 9 The Pineal Gland, Melatonin, and Neoplastic Growth: Morphological Approach.- Section III: Effects of Melatonin and of Unidentified Pineal Products on Tumor Growth.- 10 In Vitro Effects of Melatonin on Tumor Cells.- 11 Melatonin and Colon Carcinogenesis.- 12 Role of Extrapineal Melatonin and Related APUD Series Peptides in Malignancy.- 13 A Survey of the Evidence That Melatonin and Unidentified Pineal Substances Affect Neoplastic Growth.- 14 Experimental Studies of the Pineal Gland Preparation Epithalamin.- Section IV: Mechanisms of Action of Melatonin on Tumor Cells.- A. Actions Via the Endocrine System.- 15 An Overview of the Neuroendocrine Regulation of Experimental Tumor Growth by Melatonin and Its Analogues and the Therapeutic Use of Melatonin in Oncology.- 16 Modulation of the Estrogen Response Pathway in Human Breast Cancer Cells by Melatonin.- 17 Benign and Tumor Prostate Cells as Melatonin Target Sites.- B. Actions Via theImmune System.- 18 Neuroimmunomodulation Via the Autonomic Nervous System.- 19 Melatonin and Immune Functions.- 20 Melatonin and the Immune System: Therapeutic Potential in Cancer, Viral Diseases, and Immunodeficiency States.- 21 Melatonin Rhythms in Mice: Role in Autoimmune and Lymphoproliferative Diseases.- 22 Mechanisms Involved in the Immunomodulatory Effects of Melatonin on the Human Immune System.- C Actions Via Neural Pathways.- 23 The Role of the Pineal Gland in Neural Control of Cell Proliferation in Healthy and Malignant Tissue.- D. Molecular Mechanisms of Action.- 24 Reactive Oxygen Species, DNA Damage, and Carcinogenesis: Intervention with Melatonin.- 25 Could the Antiproliferative Effect of Melatonin Be Exerted Via the Interaction of Melatonin with Calmodulin and Protein Kinase C?.- Section V: Oncotherapeutic Potential of Melatonin.- 26 Efficacy of Melatonin in the Immunotherapy of Cancer Using Interleukin-2.- 27 Melatonin Cancer Therapy.- Section VI: Electromagnetic Fields and Cancer: The Possible Role of Melatonin.- 28 Circadian Disruption and Breast Cancer.- 29 Breast Cancer and Use of Electric Power: Experimental Studies on the Melatonin Hypothesis.- 30 Magnetic Field Exposure and Pineal Melatonin Production (Mini-Review).- 31 Nocturnal Hormone Profiles in Healthy Humans Under the Influence of Pulsed High-Frequency Electromagnetic Fields.- 32 Weak High-Frequency (Radiofrequency, Microwave) Electromagnetic Fields: Epidemiological Evidence of Their Impact on Cancer Development and Reproductive Outcome.
Section I: Significance of the Pineal Gland and Its Hormone Melatonin.- 1 Some Historical Remarks Concerning Research on the Pineal Gland and Cancer.- 2 Biology of the Pineal Gland and Melatonin in Humans.- 3 The Role of Melatonin in the Neuroendocrine System: Multiplicity of Sites and Mechanisms of Action.- 4 The Pineal Gland and Chronobiologic History: Mind and Spirit as Feedsidewards in Time Structures for Prehabilitation.- 5 Melatonin Involvement in Cancer: Methodological Considerations.- Section II: Effect of Tumor Growth on the Production and Secretion of Pineal Melatonin.- 6 Analysis of Melatonin in Patients with Cancer of the Reproductive System.- 7 Melatonin in Patients with Cancer of Extra-Reproductive Location.- 8 The Modulation of Melatonin in Tumor-Bearing Animals: Underlying Mechanisms and Possible Significance for Prognosis.- 9 The Pineal Gland, Melatonin, and Neoplastic Growth: Morphological Approach.- Section III: Effects of Melatonin and of Unidentified Pineal Products on Tumor Growth.- 10 In Vitro Effects of Melatonin on Tumor Cells.- 11 Melatonin and Colon Carcinogenesis.- 12 Role of Extrapineal Melatonin and Related APUD Series Peptides in Malignancy.- 13 A Survey of the Evidence That Melatonin and Unidentified Pineal Substances Affect Neoplastic Growth.- 14 Experimental Studies of the Pineal Gland Preparation Epithalamin.- Section IV: Mechanisms of Action of Melatonin on Tumor Cells.- A. Actions Via the Endocrine System.- 15 An Overview of the Neuroendocrine Regulation of Experimental Tumor Growth by Melatonin and Its Analogues and the Therapeutic Use of Melatonin in Oncology.- 16 Modulation of the Estrogen Response Pathway in Human Breast Cancer Cells by Melatonin.- 17 Benign and Tumor Prostate Cells as Melatonin Target Sites.- B. Actions Via theImmune System.- 18 Neuroimmunomodulation Via the Autonomic Nervous System.- 19 Melatonin and Immune Functions.- 20 Melatonin and the Immune System: Therapeutic Potential in Cancer, Viral Diseases, and Immunodeficiency States.- 21 Melatonin Rhythms in Mice: Role in Autoimmune and Lymphoproliferative Diseases.- 22 Mechanisms Involved in the Immunomodulatory Effects of Melatonin on the Human Immune System.- C Actions Via Neural Pathways.- 23 The Role of the Pineal Gland in Neural Control of Cell Proliferation in Healthy and Malignant Tissue.- D. Molecular Mechanisms of Action.- 24 Reactive Oxygen Species, DNA Damage, and Carcinogenesis: Intervention with Melatonin.- 25 Could the Antiproliferative Effect of Melatonin Be Exerted Via the Interaction of Melatonin with Calmodulin and Protein Kinase C?.- Section V: Oncotherapeutic Potential of Melatonin.- 26 Efficacy of Melatonin in the Immunotherapy of Cancer Using Interleukin-2.- 27 Melatonin Cancer Therapy.- Section VI: Electromagnetic Fields and Cancer: The Possible Role of Melatonin.- 28 Circadian Disruption and Breast Cancer.- 29 Breast Cancer and Use of Electric Power: Experimental Studies on the Melatonin Hypothesis.- 30 Magnetic Field Exposure and Pineal Melatonin Production (Mini-Review).- 31 Nocturnal Hormone Profiles in Healthy Humans Under the Influence of Pulsed High-Frequency Electromagnetic Fields.- 32 Weak High-Frequency (Radiofrequency, Microwave) Electromagnetic Fields: Epidemiological Evidence of Their Impact on Cancer Development and Reproductive Outcome.
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