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Sentinel lymph node is denominated as the initial focus of tumour metastasis via lymphatic effluvium from a primary tumour. Sentinel lymph node biopsy is considered as a gold standard in staging metastatic lymph nodes in breast carcinoma and melanoma. Sentinel lymph node biopsy has effectively displaced the invasive intervention of comprehensive axillary lymph node dissection ( ALND) in the management of infiltrating breast carcinoma. A dual tracer technique, a percutaneous demarcation of the biopsied node or utilization of blue dye can be cogently applied. Recommendations and guidelines for appropriately assessing the sentinel node are well delineated.