A protocolized clinical history was designed to screen patients suspected of multiple sclerosis, evaluating the functional systems of the central nervous system: cognitive sphere, cerebellum, brainstem, encephalon and spinal cord, and to know some type of demyelinating dysfunction through the computation of probabilities in percentage, where 0% (no dysfunction) and 100 % (high dysfunction). A diagnosis of exclusion will be made by comparing the patient's symptomatology with the main demyelinating diseases of the neuroaxis and with the isolated clinical syndrome. If demyelination is proven, correlate the dysfunction with the Schumacher criteria, obtaining a presumptive diagnosis of: definite, improbable, and probable multiple sclerosis.the functional disability of each patient is analyzed, the clinical activity of the disease is analyzed, and an informed consent is drawn up.