Brent Stockwell

The Quest for the Cure

The Science and Stories Behind the Next Generation of Medicines

• Gebundenes Buch

Produktbeschreibung

After more than 50 years of blockbuster drug development, skeptics fear we may be reaching the end of drug discovery to combat major diseases. A leading researcher in the exciting new science of chemical biology describes this dilemma and the powerful techniques that may bring drug research into the 21st century.

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Produktdetails

• Verlag: Columbia University Press
• Seitenzahl: 284
• Erscheinungstermin: 1. Juni 2011
• Englisch
• Abmessung: 217mm x 149mm x 24mm
• Gewicht: 445g
• ISBN-13: 9780231152129
• ISBN-10: 0231152124
• Artikelnr.: 32871004

Autorenporträt

Brent R. Stockwell is an associate professor of biological sciences and chemistry at Columbia University and a Howard Hughes Medical Institute Early Career Scientist. He serves on the editorial board of Chemistry & Biology, has been awarded ten U.S. patents, and has published fifty-four scientific papers. Among his recent honors are a Burroughs Wellcome Fund Career Award at the Scientific Interface and a Beckman Young Investigator Award.

Inhaltsangabe

List of Illustrations
Preface
Acknowledgments
Abbreviations
Part I. The Vanishing Cures
1. The Drug Discovery Crisis
2. A New Science of Molecules
3. The Birth of the First Cancer Drugs
4. A New Company Creating Drug Combinations
5. The Undruggable RAS Protein
6. The Druggable Genome
Part II. The Path to the Next Generation of Medicines
7. Peering Inside Proteins
8. The Nature of Interactions Between Proteins
9. From Protein-Protein Interactions to Personalized Medicines
10. A Revolution in Peptide Synthesis
11. A Vast Array of Drug Candidates
12. Moving Outside the Small Molecule Box
13. Accelerating the Arrival of Next-Generation Drugs
Notes
Glossary
Index